Lisdexamfetamine and Venlafaxine Interaction
Drug interaction information between Lisdexamfetamine and Venlafaxine.
Lisdexamfetamine and Venlafaxine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lisdexamfetamine and Venlafaxine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Lisdexamfetamine does not change how the body breaks down venlafaxine through liver enzymes.
FDA Label Information
7.2 Drugs Having No Clinically Important Interactions with Lisdexamfetamine Dimesylate Capsules From a pharmacokinetic perspective, no dose adjustment of lisdexamfetamine dimesylate capsules is necessary when lisdexamfetamine dimesylate capsules is co-administered with guanfacine, venlafaxine, or omeprazole. In addition, no dose adjustment of guanfacine or venlafaxine is needed when lisdexamfetamine dimesylate capsules is co-administered [see Clinical Pharmacology (12.3) ] . From a pharmacokinetic perspective, no dose adjustment for drugs that are substrates of CYP1A2 (e.g., theophylline,...
Lisdexamfetamine Also Interacts With
- Omeprazole minor
- Simvastatin minor
- Duloxetine minor
- Atomoxetine minor
- Melatonin minor
Venlafaxine Also Interacts With
- Aspirin moderate
- Phenelzine moderate
- Metoprolol minor
- Fluoxetine minor
- Alprazolam minor
Frequently Asked Questions
What SPL severity band is on file for Lisdexamfetamine + Venlafaxine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Venlafaxine has 22 labeled pairs on file vs Lisdexamfetamine's 14. In the minor band specifically: Lisdexamfetamine has 14 (also Omeprazole, Simvastatin, Duloxetine, Atomoxetine); Venlafaxine has 20 (also Metoprolol, Fluoxetine, Alprazolam, Warfarin).
What mechanism field is on file for Lisdexamfetamine and Venlafaxine?
Lisdexamfetamine does not change how the body breaks down venlafaxine through liver enzymes.
Venlafaxine's labeled portfolio outnumbers Lisdexamfetamine
SPL source-record counts only. This page's band is minor · classes on file: Lisdexamfetamine (CNS Stimulant); Venlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
0 major · 0 moderate · 14 minor · 14 total
- Other minor peers for Lisdexamfetamine
- Omeprazole
- Simvastatin
- Duloxetine
- Atomoxetine
0 major · 2 moderate · 20 minor · 22 total
- Other minor peers for Venlafaxine
- Metoprolol
- Fluoxetine
- Alprazolam
- Warfarin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.