Sucralfate and Ketoconazole Interaction
Drug interaction information between Sucralfate and Ketoconazole.
Sucralfate and Ketoconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sucralfate and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Sucralfate can block your body from absorbing ketoconazole if they are taken at the same time. This means the medicine may not work as well to treat your condition.
FDA Label Information
Drug Interactions Some studies have shown that simultaneous sucralfate administration in healthy volunteers reduced the extent of absorption (bioavailability) of single doses of the following: cimetidine, digoxin, fluoroquinolone antibiotics, ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline.
Sucralfate Also Interacts With
- Theophylline major
- Naproxen moderate
- Warfarin minor
- Ciprofloxacin minor
- Ofloxacin minor
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
What SPL severity band is on file for Sucralfate + Ketoconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Sucralfate's 20. In the minor band specifically: Sucralfate has 18 (also Warfarin, Ciprofloxacin, Ofloxacin, Tetracycline); Ketoconazole has 85 (also Abiraterone, Acetaminophen/Oxycodone, Alosetron, Amphotericin B).
What mechanism field is on file for Sucralfate and Ketoconazole?
Sucralfate can block your body from absorbing ketoconazole if they are taken at the same time. This means the medicine may not work as well to treat your condition.
Ketoconazole carries more major-labeled pairs than Sucralfate
SPL source-record counts only. This page's band is minor · classes on file: Sucralfate (Mucosal Protective Agent); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Sucralfate's 1. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 18 minor · 20 total
- Other minor peers for Sucralfate
- Warfarin
- Ciprofloxacin
- Ofloxacin
- Tetracycline
6 major · 22 moderate · 85 minor · 113 total
- Other minor peers for Ketoconazole
- Abiraterone
- Acetaminophen/Oxycodone
- Alosetron
- Amphotericin B
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.