Sucralfate and Warfarin Interaction
Drug interaction information between Sucralfate and Warfarin.
Sucralfate and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sucralfate and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medicine may interfere with how well warfarin thins your blood, although different studies have found different results.
FDA Label Information
Subtherapeutic prothrombin times with concomitant warfarin and sucralfate therapy have been reported in spontaneous and published case reports. However, two clinical studies have demonstrated no change in either serum warfarin concentration or prothrombin time with the addition of sucralfate to chronic warfarin therapy.
Sucralfate Also Interacts With
- Theophylline major
- Naproxen moderate
- Ketoconazole minor
- Ciprofloxacin minor
- Ofloxacin minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Sucralfate + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Sucralfate's 20. In the minor band specifically: Sucralfate has 18 (also Ketoconazole, Ciprofloxacin, Ofloxacin, Tetracycline); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Sucralfate and Warfarin?
This medicine may interfere with how well warfarin thins your blood, although different studies have found different results.
Warfarin carries more major-labeled pairs than Sucralfate
SPL source-record counts only. This page's band is minor · classes on file: Sucralfate (Mucosal Protective Agent); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Sucralfate's 1. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 18 minor · 20 total
- Other minor peers for Sucralfate
- Ketoconazole
- Ciprofloxacin
- Ofloxacin
- Tetracycline
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.