Sucralfate and Ciprofloxacin Interaction
Drug interaction information between Sucralfate and Ciprofloxacin.
Sucralfate and Ciprofloxacin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sucralfate and Ciprofloxacin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking sucralfate at the same time as ciprofloxacin prevents the antibiotic from being fully absorbed into your blood. This can make the antibiotic less effective at fighting your infection.
FDA Label Information
In all case studies to date (cimetidine, ciprofloxacin, digoxin, norfloxacin, ofloxacin, and ranitidine), dosing the concomitant medication 2 hours before sucralfate eliminated the interaction.
Sucralfate Also Interacts With
- Theophylline major
- Naproxen moderate
- Warfarin minor
- Ketoconazole minor
- Ofloxacin minor
Ciprofloxacin Also Interacts With
- Tizanidine major
- Cyclosporine minor
- Theophylline minor
- Carbamazepine minor
- Clozapine minor
Frequently Asked Questions
What SPL severity band is on file for Sucralfate + Ciprofloxacin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sucralfate has 20 labeled pairs on file vs Ciprofloxacin's 14. In the minor band specifically: Sucralfate has 18 (also Warfarin, Ketoconazole, Ofloxacin, Tetracycline); Ciprofloxacin has 13 (also Cyclosporine, Theophylline, Carbamazepine, Clozapine).
What mechanism field is on file for Sucralfate and Ciprofloxacin?
Taking sucralfate at the same time as ciprofloxacin prevents the antibiotic from being fully absorbed into your blood. This can make the antibiotic less effective at fighting your infection.
Sucralfate's labeled portfolio outnumbers Ciprofloxacin
SPL source-record counts only. This page's band is minor · classes on file: Sucralfate (Mucosal Protective Agent); Ciprofloxacin (Fluoroquinolone Antibiotic).
1 major · 1 moderate · 18 minor · 20 total
- Other minor peers for Sucralfate
- Warfarin
- Ketoconazole
- Ofloxacin
- Tetracycline
1 major · 0 moderate · 13 minor · 14 total
- Other minor peers for Ciprofloxacin
- Cyclosporine
- Theophylline
- Carbamazepine
- Clozapine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.