What the FDA labels say about taking them together
Ciprofloxacin and sucralfate
Ciprofloxacin's FDA label of March 2, 2026 names sucralfate in its drug interactions section, and sucralfate's label names ciprofloxacin too. The ciprofloxacin label: “Antacids, Sucralfate, Multivitamins and Other Products Containing Multivalent Cations; CIPRO should be taken at least two hours before or six hours after Multivalent cation-containing products administration.; …”
Check it at the source: the ciprofloxacin FDA label on DailyMed (effective March 2, 2026, Bayer HealthCare Pharmaceuticals Inc.); the sucralfate FDA label on DailyMed (effective September 2, 2026, Preferred Pharmaceuticals Inc.).
What does the ciprofloxacin label say about sucralfate?
Ciprofloxacin label, drug interactionsAntacids, Sucralfate, Multivitamins and Other Products Containing Multivalent Cations (magnesium/aluminum antacids; polymeric phosphate binders (for example, sevelamer, lanthanum carbonate); sucralfate; Videx ® (didanosine) chewable/buffered tablets or pediatric powder; other highly buffered drugs; or products containing calcium, iron, or zinc and dairy products); CIPRO should be taken at least two hours before or six hours after Multivalent cation-containing products administration [see Dosage and Administration ()].; Decrease CIPRO absorption, resulting in lower serum and urine levels
Source: FDA drug label (Cipro), Bayer HealthCare Pharmaceuticals Inc., effective March 2, 2026 (SPL set 888dc7f9-ad9c-4c00-8d50-8ddfd9bd27c0), via openFDA; the full label on DailyMed
What does the sucralfate label say about ciprofloxacin?
Sucralfate label, drug interactionsIn all case studies to date (cimetidine, ciprofloxacin, digoxin, norfloxacin, ofloxacin, and ranitidine), dosing the concomitant medication 2 hours before sucralfate eliminated the interaction.
Source: FDA drug label (Sucralfate, NDA019183), Pacific Pharma, Inc., effective February 10, 2024 (SPL set 7407c58e-766f-4e93-a1bb-c77892ae0174), via openFDA
Source: FDA drug label (Sucralfate), NDA018333 (Abbvie), as published by Preferred Pharmaceuticals Inc., effective September 2, 2026 (SPL set 536b8c00-13ab-4397-a754-63a1c92bf883), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ciprofloxacin | Sucralfate | |
|---|---|---|
| Labeled for | Diarrhea, Urinary tract infections, Bacterial infections | Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.123 per tablet 500 mg tablet | $0.173 per tablet 1 g tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once