Lemborexant and Fluconazole Interaction
Drug interaction information between Lemborexant and Fluconazole.
Lemborexant and Fluconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Lemborexant and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole causes a large increase in the amount of lemborexant in your body, which can make you feel dangerously sleepy.
FDA Label Information
Lemborexant: Concomitant administration of fluconazole increased lemborexant C max and AUC by approximately 1.6- and 4.2-fold, respectively which is expected to increase risk of adverse reactions, such as somnolence. Avoid concomitant use of fluconazole with lemborexant.
Lemborexant Also Interacts With
- Voriconazole moderate
- Bupropion minor
- Verapamil minor
- Carbamazepine minor
- Clarithromycin minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Lemborexant + Fluconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Lemborexant's 11. In the moderate band specifically: Lemborexant has 2 (also Voriconazole); Fluconazole has 7 (also Atorvastatin, Simvastatin, Carbamazepine, Amiodarone).
What mechanism field is on file for Lemborexant and Fluconazole?
Fluconazole causes a large increase in the amount of lemborexant in your body, which can make you feel dangerously sleepy.
Fluconazole carries more major-labeled pairs than Lemborexant
SPL source-record counts only. This page's band is moderate · classes on file: Lemborexant (Orexin Receptor Antagonist); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Lemborexant's 0. This page itself is in the moderate band, not the major band.
0 major · 2 moderate · 9 minor · 11 total
- Other moderate peers for Lemborexant
- Voriconazole
3 major · 7 moderate · 57 minor · 67 total
- Other moderate peers for Fluconazole
- Atorvastatin
- Simvastatin
- Carbamazepine
- Amiodarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.