Lemborexant and Clarithromycin Interaction
Drug interaction information between Lemborexant and Clarithromycin.
Lemborexant and Clarithromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lemborexant and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin blocks the enzyme that breaks down lemborexant in your body. This can cause the levels of the sleep medicine to rise, which may increase side effects.
FDA Label Information
Examples: Strong CYP3A inhibitors: itraconazole, clarithromycin Moderate CYP3A inhibitors: fluconazole, verapamil Weak CYP3A inhibitors: chlorzoxazone, ranitidine Strong and Moderate CYP3A Inducers Clinical Impact: Concomitant use with a strong or moderate CYP3A inducer decreases lemborexant exposure, which may reduce DAYVIGO efficacy [see Clinical Pharmacology ( 12.3 )].
Lemborexant Also Interacts With
- Fluconazole moderate
- Voriconazole moderate
- Bupropion minor
- Verapamil minor
- Carbamazepine minor
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Lemborexant + Clarithromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Lemborexant's 11. In the minor band specifically: Lemborexant has 9 (also Bupropion, Verapamil, Carbamazepine, Rifampin); Clarithromycin has 30 (also Amlodipine, Lorazepam, Diltiazem, Erythromycin).
What mechanism field is on file for Lemborexant and Clarithromycin?
Clarithromycin blocks the enzyme that breaks down lemborexant in your body. This can cause the levels of the sleep medicine to rise, which may increase side effects.
Clarithromycin carries more major-labeled pairs than Lemborexant
SPL source-record counts only. This page's band is minor · classes on file: Lemborexant (Orexin Receptor Antagonist); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Lemborexant's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 9 minor · 11 total
- Other minor peers for Lemborexant
- Bupropion
- Verapamil
- Carbamazepine
- Rifampin
16 major · 35 moderate · 30 minor · 81 total
- Other minor peers for Clarithromycin
- Amlodipine
- Lorazepam
- Diltiazem
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.