Prescription medication · Orexin Receptor Antagonist
lemborexant
Also sold as Dayvigo. Dayvigo is used to treat insomnia in adults.
Data updated 2026-05-15
- 2,425
- FDA reportsLightly reported
- 11
- InteractionsSeveral interactions
- $10.79
- Brand price (NADAC)
What the data shows
lemborexant (Dayvigo) is a prescription Orexin Receptor Antagonist, among the least-reported drugs the FDA tracks (2,425 FDA reports), with 11 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
lemborexant (Dayvigo) is a prescription Orexin Receptor Antagonist. Dayvigo is used to treat insomnia in adults.
Dayvigo is a medicine that can help you fall asleep and stay asleep. It is for adults who have trouble with insomnia.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Brand Price
$10.79/unit
Generic Available
No
EISAI INC
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Dayvigo is used to treat insomnia in adults.
Common side effects
Feeling sleepy
Key warnings
Dayvigo can make you feel very sleepy, even the next day.
The sections below are summarized in plain English from lemborexant's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Dayvigo works by blocking orexin, a chemical in your brain that keeps you awake. By blocking orexin, Dayvigo helps you feel sleepy. This allows you to fall asleep and stay asleep.
How to Take It
Take Dayvigo right before you go to bed. Only take it once per night. Make sure you have at least 7 hours to sleep before you wake up. You can start with 5 mg, and your doctor may increase it to 10 mg.
This is a plain-language summary of lemborexant's FDA labeling, not individualized dosing advice. Ask a pharmacist or prescriber before changing how you take this medication.
Pregnancy & Breastfeeding
It is not known if Dayvigo can harm your unborn baby. If you are pregnant or plan to become pregnant, talk to your doctor. There is a pregnancy registry for women who take psychiatric medicines, including Dayvigo.
This is a plain-language summary of lemborexant's FDA labeling, not individualized advice. Ask a pharmacist or prescriber about pregnancy or breastfeeding on this medication.
Missed Dose
If you forget to take Dayvigo before bed, skip that dose. Do not take a double dose to make up for it.
This is a plain-language summary of lemborexant's FDA labeling, not individualized advice. Ask a pharmacist or prescriber what to do about your specific missed dose.
Storage
Store Dayvigo at room temperature, between 68°F and 77°F.
Side Effects (from patient reports)
Based on 2,425 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for lemborexant, by number of reports
- Trying to kill oneself
Trying to kill oneself
133 reports
- Feeling sleepy
Feeling sleepy
128 reports
- The health problem got worse
The health problem got worse
117 reports
- Thinking about killing oneself
Thinking about killing oneself
115 reports
- Falling down
Falling down
94 reports
- Head pain
Head pain
84 reports
- Being unable to move or speak while waking up or falling asleep
Being unable to move or speak while waking up or falling asleep
82 reports
- Feeling sick to your stomach
Feeling sick to your stomach
80 reports
- Feeling lightheaded or unsteady
Feeling lightheaded or unsteady
76 reports
- Trouble sleeping
Trouble sleeping
75 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for lemborexant each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where lemborexant sits
lemborexant has more FDA adverse-event reports than 15% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is lemborexant; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 2,425 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2015–2025.
Total Reports
2,425
Reports Mentioning Death
267
11.0% of reports — not proof of cause
Hospitalization Reports
1,064
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 3 | SUICIDE ATTEMPT | 133 |
| 4 | SOMNOLENCE | 128 |
| 5 | CONDITION AGGRAVATED | 117 |
| 6 | SUICIDAL IDEATION | 115 |
| 7 | FALL | 94 |
| 8 | HEADACHE | 84 |
| 9 | SLEEP PARALYSIS | 82 |
| 10 | NAUSEA | 80 |
| 11 | DIZZINESS | 76 |
| 12 | INSOMNIA | 75 |
| 13 | NIGHTMARE | 74 |
| 14 | PYREXIA | 68 |
| 15 | MALAISE | 66 |
| 16 | HEPATIC FUNCTION ABNORMAL | 64 |
| 17 | ADVERSE DRUG REACTION | 62 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Dayvigo can make you feel very sleepy, even the next day. Be careful driving or doing other things that need you to be alert. Some people have sleep paralysis, hallucinations, or do things like sleepwalking while taking Dayvigo. Dayvigo may also worsen depression or suicidal thoughts. Do not drink alcohol while taking Dayvigo.
Known Drug Interactions
Lemborexant: Concomitant administration of fluconazole increased lemborexant C max and AUC by approximately 1.6- and 4.2-fold, respectively which is expected to increase risk of adverse reactions, such as somnolence. Avoid concomitant use of fluconazole with lemborexant.
Mechanism: Fluconazole causes a large increase in the amount of lemborexant in your body, which can make you feel dangerously sleepy.
What to do: You should avoid taking these two medications at the same time.
Lemborexant (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased Avoid concomitant use of VFEND with lemborexant.
Mechanism: Voriconazole prevents the body from processing lemborexant correctly, which can cause the sleep medication to build up to unsafe levels.
What to do: You should not take these two medications at the same time.
Examples: Bupropion, methadone
Mechanism: Lemborexant can speed up the process of clearing bupropion from your system, potentially making it less effective.
What to do: Watch for changes in how well your medication is working and report them to your healthcare provider.
Examples: Strong CYP3A inhibitors: itraconazole, clarithromycin Moderate CYP3A inhibitors: fluconazole, verapamil Weak CYP3A inhibitors: chlorzoxazone, ranitidine Strong and Moderate CYP3A Inducers Clinical Impact: Concomitant use with a strong or moderate CYP3A inducer decreases lemborexant exposure, which may reduce DAYVIGO efficacy [see Clinical Pharmacology ( 12.3 )].
Mechanism: Verapamil slows down how your body gets rid of lemborexant, which can cause the sleep medicine to build up in your system.
What to do: Your doctor may need to lower your dose of lemborexant to avoid excessive sleepiness.
Examples: Strong CYP3A inducers: rifampin, carbamazepine, St.
Mechanism: Carbamazepine causes your body to process lemborexant much faster, which makes the sleep medicine less effective.
What to do: Avoid using these medications together because the sleep medicine likely will not work as intended.
This is a plain-language summary of interactions documented in FDA labeling, not individualized advice. Ask a pharmacist or prescriber before combining medications.
Common Questions
Can I drive after taking Dayvigo?
Can I drink alcohol with Dayvigo?
What should I do if I have strange experiences while taking Dayvigo?
Can Dayvigo make my depression worse?
What if Dayvigo stops working after a few weeks?
Can I take other sleep medicines with Dayvigo?
What if I have liver problems?
What if I am taking other medications?
How long does Dayvigo stay in my system?
What do the Dayvigo tablets look like?
What are the common side effects of lemborexant?
Does lemborexant interact with other medications?
What drug class is lemborexant?
Is lemborexant safe during pregnancy?
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Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
Why some drugs demand precise dosing and monitoring
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
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What the FDA Data Shows for lemborexant
The FDA label for lemborexant (sold under brand names such as Dayvigo) classifies it as a prescription-only medication in the Orexin Receptor Antagonist class. Dayvigo is used to treat insomnia in adults. Official labeling lists 1 commonly reported side effect, including Feeling sleepy.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 2,425 voluntary reports. The database also lists 11 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated moderate severity. NADAC pricing from CMS.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice, always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: February 24, 2025
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled and last refreshed May 2026. See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a correction.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages