Lemborexant and Bupropion Interaction
Drug interaction information between Lemborexant and Bupropion.
Lemborexant and Bupropion have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lemborexant and Bupropion. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Lemborexant can speed up the process of clearing bupropion from your system, potentially making it less effective.
FDA Label Information
Examples: Bupropion, methadone
Lemborexant Also Interacts With
- Fluconazole moderate
- Voriconazole moderate
- Verapamil minor
- Carbamazepine minor
- Clarithromycin minor
Bupropion Also Interacts With
- Tranylcypromine major
- Theophylline moderate
- Isavuconazonium moderate
- Metoprolol minor
- Sertraline minor
Frequently Asked Questions
What SPL severity band is on file for Lemborexant + Bupropion?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Bupropion has 35 labeled pairs on file vs Lemborexant's 11. In the minor band specifically: Lemborexant has 9 (also Verapamil, Carbamazepine, Clarithromycin, Rifampin); Bupropion has 32 (also Metoprolol, Sertraline, Fluoxetine, Clopidogrel).
What mechanism field is on file for Lemborexant and Bupropion?
Lemborexant can speed up the process of clearing bupropion from your system, potentially making it less effective.
Bupropion carries more major-labeled pairs than Lemborexant
SPL source-record counts only. This page's band is minor · classes on file: Lemborexant (Orexin Receptor Antagonist); Bupropion (Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)).
Bupropion has 1 major-labeled pair vs Lemborexant's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 9 minor · 11 total
- Other minor peers for Lemborexant
- Verapamil
- Carbamazepine
- Clarithromycin
- Rifampin
1 major · 2 moderate · 32 minor · 35 total
- Other minor peers for Bupropion
- Metoprolol
- Sertraline
- Fluoxetine
- Clopidogrel
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.