What the FDA labels say about taking them together
Bupropion and lemborexant
Lemborexant's FDA label of February 24, 2025 names bupropion in its drug interactions section; the bupropion labels PlainMeds reads (4) do not name lemborexant. The lemborexant label: “Concomitant use of DAYVIGO decreases the AUC of drugs that are CYP2B6 substrates, which may result in reduced efficacy for these concomitant medications.”
Check it at the source: the bupropion FDA label on DailyMed (effective June 21, 2024); the lemborexant FDA label on DailyMed (effective February 24, 2025, Eisai Inc.).
What does the bupropion label say about lemborexant?
Bupropion's label (effective June 21, 2024) and its 3 other brand-application labels do not name lemborexant in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (BUPROPION HYDROCHLORIDE), Epic Pharma LLC, effective June 21, 2024 (SPL set 9fb44e96-6160-4a4a-90cb-91764c0dcd89), via openFDA; the full label on DailyMed
What does the lemborexant label say about bupropion?
Lemborexant label, drug interactionsCYP2B6 Substrates Clinical Impact: Concomitant use of DAYVIGO decreases the AUC of drugs that are CYP2B6 substrates, which may result in reduced efficacy for these concomitant medications. Intervention: Patients receiving DAYVIGO and CYP2B6 substrates concurrently should be monitored for adequate clinical response. Increasing the doses of CYP2B6 substrates may be considered as needed. Examples: Bupropion, methadone
Source: FDA drug label (DAYVIGO), Eisai Inc., effective February 24, 2025 (SPL set 7074cb65-77b3-45d2-8e8d-da8dc0f70bfd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bupropion | Lemborexant | |
|---|---|---|
| Labeled for | Depression, Quitting smoking | Insomnia |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0785 per tablet 150 mg tablet | $11.57 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once