fluconazole vs lemborexant
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Side-by-side comparison of fluconazole and lemborexant. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Lemborexant: Concomitant administration of fluconazole increased lemborexant C max and AUC by approximately 1.6- and 4.2-fold, respectively which is expected to increase risk of adverse reactions, such as somnolence. Avoid concomitant use of fluconazole with lemborexant.
Diflucan
Dayvigo
Fluconazole is an antifungal medicine. It is used to treat infections caused by fungus.
Dayvigo is a medicine that can help you fall asleep and stay asleep. It is for adults who have trouble with insomnia.
Fluconazole treats vaginal yeast infections. It also treats yeast infections in the mouth and esophagus. Fluconazole can also treat urinary tract infections, peritonitis, systemic Candida infections, and pneumonia. It can also treat cryptococcal meningitis. Fluconazole can also prevent candidiasis in patients undergoing bone marrow transplantation.
Dayvigo is used to treat insomnia in adults. Insomnia means you have trouble falling asleep, staying asleep, or both. This medicine can help you sleep better.
Fluconazole works by stopping the growth of fungi. It blocks the fungus from producing a substance it needs to grow. This helps to clear up the infection.
Dayvigo works by blocking orexin, a chemical in your brain that keeps you awake. By blocking orexin, Dayvigo helps you feel sleepy. This allows you to fall asleep and stay asleep.
- • Headache
- • Nausea
- • Abdominal pain
- • Feeling sleepy
- Pyrexia 4,121
- Nausea 3,697
- Diarrhoea 3,538
- Fatigue 3,151
- Pain 3,123
- Suicide Attempt 133
- Somnolence 128
- Condition Aggravated 117
- Suicidal Ideation 115
- Fall 94
Coadministration of other drugs known to prolong the QT interval and which are metabolized via the enzyme CYP3A4 such as erythromycin, pimozide, and quinidine are contraindicated in patients receiving fluconazole.
Dayvigo can make you feel very sleepy, even the next day. Be careful driving or doing other things that need you to be alert. Some people have sleep paralysis, hallucinations, or do things like sleepwalking while taking Dayvigo. Dayvigo may also worsen depression or suicidal thoughts. Do not drink alcohol while taking Dayvigo.
Tell your doctor if you are pregnant or plan to become pregnant. Fluconazole may not be safe for your baby. Talk to your doctor about breastfeeding while taking fluconazole.
It is not known if Dayvigo can harm your unborn baby. If you are pregnant or plan to become pregnant, talk to your doctor. There is a pregnancy registry for women who take psychiatric medicines, including Dayvigo.
Also Compare, Nearby Drugs
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How to Read This fluconazole vs lemborexant Comparison
fluconazole is classified in the Azole Antifungal drug class, while lemborexant sits within the Orexin Receptor Antagonist class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluconazole has 17,630 submissions while lemborexant has 587. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to fluconazole causes a large increase in the amount of lemborexant in your body, which can make you feel dangerously sleepy.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for fluconazole or lemborexant.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.