Lemborexant and Verapamil Interaction
Drug interaction information between Lemborexant and Verapamil.
Lemborexant and Verapamil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lemborexant and Verapamil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Verapamil slows down how your body gets rid of lemborexant, which can cause the sleep medicine to build up in your system.
FDA Label Information
Examples: Strong CYP3A inhibitors: itraconazole, clarithromycin Moderate CYP3A inhibitors: fluconazole, verapamil Weak CYP3A inhibitors: chlorzoxazone, ranitidine Strong and Moderate CYP3A Inducers Clinical Impact: Concomitant use with a strong or moderate CYP3A inducer decreases lemborexant exposure, which may reduce DAYVIGO efficacy [see Clinical Pharmacology ( 12.3 )].
Lemborexant Also Interacts With
- Fluconazole moderate
- Voriconazole moderate
- Bupropion minor
- Carbamazepine minor
- Clarithromycin minor
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Lemborexant + Verapamil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Lemborexant's 11. In the minor band specifically: Lemborexant has 9 (also Bupropion, Carbamazepine, Clarithromycin, Rifampin); Verapamil has 47 (also Atorvastatin, Aspirin, Atenolol, Timolol).
What mechanism field is on file for Lemborexant and Verapamil?
Verapamil slows down how your body gets rid of lemborexant, which can cause the sleep medicine to build up in your system.
Verapamil carries more major-labeled pairs than Lemborexant
SPL source-record counts only. This page's band is minor · classes on file: Lemborexant (Orexin Receptor Antagonist); Verapamil (Calcium Channel Blocker).
Verapamil has 4 major-labeled pairs vs Lemborexant's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 9 minor · 11 total
- Other minor peers for Lemborexant
- Bupropion
- Carbamazepine
- Clarithromycin
- Rifampin
4 major · 6 moderate · 47 minor · 57 total
- Other minor peers for Verapamil
- Atorvastatin
- Aspirin
- Atenolol
- Timolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.