Fluconazole and Amiodarone Interaction
Drug interaction information between Fluconazole and Amiodarone.
Fluconazole and Amiodarone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Fluconazole and Amiodarone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these drugs together can affect the electrical timing of your heartbeat, which may lead to a dangerous heart rhythm.
FDA Label Information
Amiodarone : Concomitant administration of fluconazole with amiodarone may increase QT prolongation. Caution must be exercised if the concomitant use of fluconazole and amiodarone is necessary, notably with high-dose fluconazole (800 mg).
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Lithium moderate
Frequently Asked Questions
What SPL severity band is on file for Fluconazole + Amiodarone?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Amiodarone's 42. In the moderate band specifically: Fluconazole has 7 (also Atorvastatin, Simvastatin, Carbamazepine, Fluvastatin); Amiodarone has 9 (also Lithium, Clarithromycin, Ledipasvir/Sofosbuvir, Lovastatin).
What mechanism field is on file for Fluconazole and Amiodarone?
Using these drugs together can affect the electrical timing of your heartbeat, which may lead to a dangerous heart rhythm.
Amiodarone carries more major-labeled pairs than Fluconazole
SPL source-record counts only. This page's band is moderate · classes on file: Fluconazole (Azole Antifungal); Amiodarone (Class III Antiarrhythmic).
Amiodarone has 4 major-labeled pairs vs Fluconazole's 3. This page itself is in the moderate band, not the major band.
3 major · 7 moderate · 57 minor · 67 total
- Other moderate peers for Fluconazole
- Atorvastatin
- Simvastatin
- Carbamazepine
- Fluvastatin
4 major · 9 moderate · 29 minor · 42 total
- Other moderate peers for Amiodarone
- Lithium
- Clarithromycin
- Ledipasvir/Sofosbuvir
- Lovastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.