Isradipine and Digoxin Interaction
Drug interaction information between Isradipine and Digoxin.
Isradipine and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Isradipine and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Isradipine does not change how your body removes digoxin from your system.
FDA Label Information
Digoxin: The concomitant administration of isradipine and digoxin in a single-dose pharmacokinetic study did not affect renal, nonrenal and total body clearance of digoxin.
Isradipine Also Interacts With
- Theophylline major
- Hydrochlorothiazide minor
- Propranolol minor
- Warfarin minor
- Nitroglycerin minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Isradipine + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Isradipine's 9. In the minor band specifically: Isradipine has 8 (also Hydrochlorothiazide, Propranolol, Warfarin, Nitroglycerin); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Isradipine and Digoxin?
Isradipine does not change how your body removes digoxin from your system.
Digoxin carries more major-labeled pairs than Isradipine
SPL source-record counts only. This page's band is minor · classes on file: Isradipine (Calcium Channel Blocker); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Isradipine's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 8 minor · 9 total
- Other minor peers for Isradipine
- Hydrochlorothiazide
- Propranolol
- Warfarin
- Nitroglycerin
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.