digoxin vs isradipine
According to this portal's Publishing Organization, this page was last reviewed in August 2026 against our methodology. Figures and extracts on this site, including tables above 1,000 rows when the corpus is that large, are the publisher's responsibility.
Side-by-side comparison of digoxin and isradipine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Digoxin: The concomitant administration of isradipine and digoxin in a single-dose pharmacokinetic study did not affect renal, nonrenal and total body clearance of digoxin.
Lanoxin
DynaCirc
Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.
Isradipine is a drug that helps lower high blood pressure. It belongs to a class of drugs called calcium channel blockers.
Digoxin is used to treat mild to moderate heart failure in adults. It helps the heart pump more blood with each beat. Digoxin is also used in children with heart failure to help their heart work better. In adults, it can control a fast and irregular heartbeat called atrial fibrillation.
Isradipine capsules are used to treat high blood pressure. You can take it alone or with a thiazide diuretic (water pill). It may take 2 to 4 weeks to see the full effect.
Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.
Isradipine blocks calcium from entering certain cells. This action relaxes blood vessels, which lowers blood pressure. Lowering blood pressure helps prevent strokes, heart attacks, and kidney problems.
- • Nausea
- • Vomiting
- • Diarrhea
- • Dizziness
- • Headache
- • Headache
- • Dizziness
- • Swelling in ankles or feet
- • Feeling your heart beat rapidly or irregularly
- • Fatigue
- Dyspnoea 6,065
- Nausea 4,754
- Dizziness 4,439
- Fatigue 4,175
- Atrial Fibrillation 3,974
- Drug Interaction 32
- Dyspnoea 31
- Hypertension 29
- Acute Kidney Injury 26
- Nausea 26
Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.
If you are taking cimetidine, your doctor should watch you closely for side effects when you start isradipine. If you are taking rifampicin, isradipine may not work as well.
It is not known if digoxin can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. The medicine passes into breast milk, but it is unlikely to harm the baby.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if isradipine will harm your unborn baby. Talk to your doctor about the risks and benefits of taking isradipine while breastfeeding.
Also Compare, Nearby Drugs
Compare isradipine with
How to Read This digoxin vs isradipine Comparison
digoxin is classified in the Cardiac Glycoside drug class, while isradipine sits within the Calcium Channel Blocker class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, digoxin has 23,407 submissions while isradipine has 144. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to isradipine does not change how your body removes digoxin from your system.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for digoxin or isradipine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.