What the FDA labels say about taking them together
Isradipine and propranolol
Isradipine's FDA label of November 30, 2023 names propranolol in its drug interactions section; propranolol's label does not name isradipine itself but warns about its class (Calcium channel blockers (dihydropyridines)). The isradipine label: “Significant increases in AUC (27%) and C max (58%) and decreases in t max (23%) of propranolol were noted in this study.”
Check it at the source: the isradipine FDA label on DailyMed (effective November 30, 2023, Teva Pharmaceuticals USA, Inc.); the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.).
What does the isradipine label say about propranolol?
Isradipine label, drug interactionsSignificant increases in AUC (27%) and C max (58%) and decreases in t max (23%) of propranolol were noted in this study.
Source: FDA drug label (Isradipine), Teva Pharmaceuticals USA, Inc., effective November 30, 2023 (SPL set bf3425e0-428d-4bdb-ac9a-3b9d483df83a), via openFDA; the full label on DailyMed
What does the propranolol label say about isradipine?
Propranolol's label does not name isradipine itself; it warns about its class (Calcium channel blockers (dihydropyridines)):
Propranolol label, drug interactionsCalcium Channel Blockers The mean C max and AUC of propranolol are increased, respectively, by 50% and 30% by co-administration of nisoldipine and by 80% and 47%, by co-administration of nicardipine.
Propranolol label, drug interactionsCaution should be exercised when administering propranolol hydrochloride tablets with drugs that slow A-V nodal conduction, e.g., digitalis, lidocaine and calcium channel blockers.
Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Isradipine | Propranolol | |
|---|---|---|
| Labeled for | High blood pressure | High blood pressure, Angina, Atrial fibrillation, Migraine |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.70 per capsule 5 mg capsule | $0.0493 per tablet 20 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once