Isradipine and Propranolol Interaction
Drug interaction information between Isradipine and Propranolol.
Isradipine and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Isradipine and Propranolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these drugs together may temporarily change how much medicine is in your blood, but this effect usually disappears after a few days of regular use.
FDA Label Information
Propranolol: In a single dose study in normal volunteers, co-administration of propranolol had a small effect on the rate but no effect on the extent of isradipine bioavailability. Significant increases in AUC (27%) and C max (58%) and decreases in t max (23%) of propranolol were noted in this study. propranolol to healthy volunteers under steady-state conditions had no relevant effect on either drug's bioavailability.
Isradipine Also Interacts With
- Theophylline major
- Hydrochlorothiazide minor
- Warfarin minor
- Digoxin minor
- Nitroglycerin minor
Frequently Asked Questions
What SPL severity band is on file for Isradipine + Propranolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propranolol has 44 labeled pairs on file vs Isradipine's 9. In the minor band specifically: Isradipine has 8 (also Hydrochlorothiazide, Warfarin, Digoxin, Nitroglycerin); Propranolol has 44 (also Clonidine, Diltiazem, Warfarin, Verapamil).
What mechanism field is on file for Isradipine and Propranolol?
Taking these drugs together may temporarily change how much medicine is in your blood, but this effect usually disappears after a few days of regular use.
Isradipine carries more major-labeled pairs than Propranolol
SPL source-record counts only. This page's band is minor · classes on file: Isradipine (Calcium Channel Blocker); Propranolol (Non-Selective Beta-Blocker).
Isradipine has 1 major-labeled pair vs Propranolol's 0. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 8 minor · 9 total
- Other minor peers for Isradipine
- Hydrochlorothiazide
- Warfarin
- Digoxin
- Nitroglycerin
0 major · 0 moderate · 44 minor · 44 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.