Glecaprevir/Pibrentasvir and Simvastatin Interaction
Drug interaction information between Glecaprevir/Pibrentasvir and Simvastatin.
Glecaprevir/Pibrentasvir and Simvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glecaprevir/Pibrentasvir and Simvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Glecaprevir and pibrentasvir can cause simvastatin levels to rise in the body. This happens because the medicine interferes with how the body processes the statin.
FDA Label Information
HMG-CoA Reductase Inhibitors: Atorvastatin Lovastatin Simvastatin ↑ atorvastatin ↑ lovastatin ↑ simvastatin Coadministration may increase the concentration of atorvastatin, lovastatin, and simvastatin.
Glecaprevir/Pibrentasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Cyclosporine moderate
- Darunavir moderate
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Glecaprevir/Pibrentasvir + Simvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Simvastatin has 41 labeled pairs on file vs Glecaprevir/Pibrentasvir's 38. In the minor band specifically: Glecaprevir/Pibrentasvir has 26 (also Atorvastatin, Amlodipine, Losartan, Omeprazole); Simvastatin has 21 (also Fenofibrate, Ketoconazole, Erythromycin, Clarithromycin).
What mechanism field is on file for Glecaprevir/Pibrentasvir and Simvastatin?
Glecaprevir and pibrentasvir can cause simvastatin levels to rise in the body. This happens because the medicine interferes with how the body processes the statin.
Simvastatin carries more major-labeled pairs than Glecaprevir/Pibrentasvir
SPL source-record counts only. This page's band is minor · classes on file: Glecaprevir/Pibrentasvir (NS3/4A/NS5A Inhibitor (HCV)); Simvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Simvastatin has 11 major-labeled pairs vs Glecaprevir/Pibrentasvir's 3. This page itself is in the minor band, not the major band.
3 major · 9 moderate · 26 minor · 38 total
- Other minor peers for Glecaprevir/Pibrentasvir
- Atorvastatin
- Amlodipine
- Losartan
- Omeprazole
11 major · 9 moderate · 21 minor · 41 total
- Other minor peers for Simvastatin
- Fenofibrate
- Ketoconazole
- Erythromycin
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.