Gentamicin and Piperacillin/Tazobactam Interaction
Drug interaction information between Gentamicin and Piperacillin/Tazobactam.
Gentamicin and Piperacillin/Tazobactam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Gentamicin and Piperacillin/Tazobactam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs can be safely given through the same IV line at the same time as long as specific liquids and amounts are used.
FDA Label Information
ZOSYN, which contains EDTA, is compatible with amikacin and gentamicin for simultaneous Y-site infusion in certain diluents and at specific concentrations.
Gentamicin Also Interacts With
- Cidofovir major
- Bictegravir/Emtricitabine/Tenofovir minor
- Digoxin minor
- Emtricitabine/Tenofovir minor
- Perindopril minor
Piperacillin/Tazobactam Also Interacts With
- Probenecid moderate
- Methotrexate minor
- Vancomycin minor
- Tobramycin minor
- Amikacin minor
Frequently Asked Questions
What SPL severity band is on file for Gentamicin + Piperacillin/Tazobactam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's minor band?
Gentamicin and Piperacillin/Tazobactam tie at 7 labeled pairs each. minor-band counts: Gentamicin 6 alongside Bictegravir, Digoxin, Emtricitabine/Tenofovir, Perindopril; Piperacillin/Tazobactam 6 alongside Methotrexate, Vancomycin, Tobramycin, Amikacin.
What mechanism field is on file for Gentamicin and Piperacillin/Tazobactam?
These drugs can be safely given through the same IV line at the same time as long as specific liquids and amounts are used.
Gentamicin carries more major-labeled pairs than Piperacillin/Tazobactam
SPL source-record counts only. This page's band is minor · classes on file: Gentamicin (Aminoglycoside Antibiotic); Piperacillin/Tazobactam (Penicillin / Beta-Lactamase Inhibitor).
Gentamicin has 1 major-labeled pair vs Piperacillin/Tazobactam's 0. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 6 minor · 7 total
- Other minor peers for Gentamicin
- Bictegravir
- Digoxin
- Emtricitabine/Tenofovir
- Perindopril
0 major · 1 moderate · 6 minor · 7 total
- Other minor peers for Piperacillin/Tazobactam
- Methotrexate
- Vancomycin
- Tobramycin
- Amikacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.