What the FDA labels say about taking them together
Fluoxetine and imipramine
Fluoxetine's FDA label of January 8, 2026 names imipramine in its drug interactions section, and imipramine's label names fluoxetine too. The imipramine label: “While all the selective serotonin reuptake inhibitors (SSRIs), e.g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition.”
Check it at the source: the fluoxetine FDA label on DailyMed (effective January 8, 2026, Dista Products Company); the imipramine FDA label on DailyMed (effective August 11, 2026, Leading Pharma, LLC).
What does the fluoxetine label say about imipramine?
Fluoxetine label, drug interactionsTricyclic Antidepressants (TCAs) – In 2 studies, previously stable plasma levels of imipramine and desipramine have increased greater than 2- to 10-fold when fluoxetine has been administered in combination.
Source: FDA drug label (Prozac), NDA018936 (Eli Lilly And Co), as published by Dista Products Company, effective January 8, 2026 (SPL set c88f33ed-6dfb-4c5e-bc01-d8e36dd97299), via openFDA; the full label on DailyMed
What does the imipramine label say about fluoxetine?
Imipramine label, drug interactionsWhile all the selective serotonin reuptake inhibitors (SSRIs), e.g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition.
Source: FDA drug label (Imipramine Hydrochloride), Leading Pharma, LLC, effective August 11, 2026 (SPL set 490263ce-b4d2-428a-87da-fcd07f85499a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluoxetine | Imipramine | |
|---|---|---|
| Labeled for | Depression, Anxiety, Bipolar disorder | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0519 per capsule 40 mg capsule | $0.0698 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once