Fluoxetine and Imipramine Interaction
Drug interaction information between Fluoxetine and Imipramine.
Fluoxetine and Imipramine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fluoxetine and Imipramine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine prevents your body from breaking down imipramine normally. This can cause imipramine to build up to very high and potentially unsafe levels in your system.
FDA Label Information
Tricyclic Antidepressants (TCAs) — In 2 studies, previously stable plasma levels of imipramine and desipramine have increased greater than 2- to 10-fold when fluoxetine has been administered in combination.
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Imipramine Also Interacts With
- Epinephrine moderate
- Norepinephrine moderate
- Zolpidem moderate
- Sertraline minor
- Paroxetine minor
Frequently Asked Questions
What SPL severity band is on file for Fluoxetine + Imipramine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Imipramine's 20. In the minor band specifically: Fluoxetine has 43 (also Ketoconazole, Lithium, Moxifloxacin, Erythromycin); Imipramine has 17 (also Sertraline, Paroxetine, Flecainide, Propafenone).
What mechanism field is on file for Fluoxetine and Imipramine?
Fluoxetine prevents your body from breaking down imipramine normally. This can cause imipramine to build up to very high and potentially unsafe levels in your system.
Fluoxetine carries more major-labeled pairs than Imipramine
SPL source-record counts only. This page's band is minor · classes on file: Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)); Imipramine (Tricyclic Antidepressant (TCA)).
Fluoxetine has 6 major-labeled pairs vs Imipramine's 0. This page itself is in the minor band, not the major band.
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Moxifloxacin
- Erythromycin
0 major · 3 moderate · 17 minor · 20 total
- Other minor peers for Imipramine
- Sertraline
- Paroxetine
- Flecainide
- Propafenone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.