Felbamate and Erythromycin Interaction
Drug interaction information between Felbamate and Erythromycin.
Felbamate and Erythromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Felbamate and Erythromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Erythromycin does not change the amount of felbamate that stays in your system.
FDA Label Information
Effects of Erythromycin on Felbamate The coadministration of erythromycin (1000 mg/day) for 10 days did not alter the pharmacokinetic parameters of C max , C min , AUC, Cl/kg or T max at felbamate daily doses of 3000 or 3600 mg/day in 10 otherwise healthy subjects with epilepsy.
Felbamate Also Interacts With
- Clonazepam major
- Phenobarbital minor
- Carbamazepine minor
- Drospirenone/Ethinyl Estradiol minor
- Estradiol minor
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lefamulin moderate
Frequently Asked Questions
What SPL severity band is on file for Felbamate + Erythromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Felbamate's 16. In the minor band specifically: Felbamate has 15 (also Phenobarbital, Carbamazepine, Drospirenone, Estradiol); Erythromycin has 53 (also Acetaminophen/Oxycodone, Alprazolam, Atorvastatin, Bromocriptine).
What mechanism field is on file for Felbamate and Erythromycin?
Erythromycin does not change the amount of felbamate that stays in your system.
Erythromycin carries more major-labeled pairs than Felbamate
SPL source-record counts only. This page's band is minor · classes on file: Felbamate (Anticonvulsant); Erythromycin (Macrolide Antibiotic).
Erythromycin has 4 major-labeled pairs vs Felbamate's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 15 minor · 16 total
- Other minor peers for Felbamate
- Phenobarbital
- Carbamazepine
- Drospirenone
- Estradiol
4 major · 6 moderate · 53 minor · 63 total
- Other minor peers for Erythromycin
- Acetaminophen/Oxycodone
- Alprazolam
- Atorvastatin
- Bromocriptine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.