Felbamate and Estradiol Interaction
Drug interaction information between Felbamate and Estradiol.
Felbamate and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Felbamate and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Felbamate causes your body to process estradiol more quickly, which lowers the amount of medicine in your system.
FDA Label Information
Examples Aprepitant, barbiturates, bosentan, carbamazepine, efavirenz, felbamate, griseofulvin, oxcarbazepine, phenytoin, rifampin, rifabutin, rufinamide, topiramate, products containing St.
Felbamate Also Interacts With
- Clonazepam major
- Erythromycin minor
- Phenobarbital minor
- Carbamazepine minor
- Drospirenone/Ethinyl Estradiol minor
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
What SPL severity band is on file for Felbamate + Estradiol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Felbamate's 16. In the minor band specifically: Felbamate has 15 (also Erythromycin, Phenobarbital, Carbamazepine, Drospirenone); Estradiol has 50 (also Rosuvastatin, Lamotrigine, Topiramate, Tizanidine).
What mechanism field is on file for Felbamate and Estradiol?
Felbamate causes your body to process estradiol more quickly, which lowers the amount of medicine in your system.
Estradiol's labeled portfolio outnumbers Felbamate
SPL source-record counts only. This page's band is minor · classes on file: Felbamate (Anticonvulsant); Estradiol (Estrogen Hormone).
1 major · 0 moderate · 15 minor · 16 total
- Other minor peers for Felbamate
- Erythromycin
- Phenobarbital
- Carbamazepine
- Drospirenone
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Topiramate
- Tizanidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.