Felbamate and Carbamazepine Interaction
Drug interaction information between Felbamate and Carbamazepine.
Felbamate and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Felbamate and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Felbamate causes your body to process carbamazepine more quickly, which can lead to lower levels of the drug in your system.
FDA Label Information
Drugs that have been shown, or that would be expected, to decrease plasma carbamazepine levels include cisplatin, doxorubicin HCl, felbamate, fosphenytoin, rifampin, phenobarbital, phenytoin, primidone, methsuximide, theophylline, aminophylline.
Felbamate Also Interacts With
- Clonazepam major
- Erythromycin minor
- Phenobarbital minor
- Drospirenone/Ethinyl Estradiol minor
- Estradiol minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Felbamate + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Felbamate's 16. In the minor band specifically: Felbamate has 15 (also Erythromycin, Phenobarbital, Drospirenone, Estradiol); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Felbamate and Carbamazepine?
Felbamate causes your body to process carbamazepine more quickly, which can lead to lower levels of the drug in your system.
Carbamazepine carries more major-labeled pairs than Felbamate
SPL source-record counts only. This page's band is minor · classes on file: Felbamate (Anticonvulsant); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Felbamate's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 15 minor · 16 total
- Other minor peers for Felbamate
- Erythromycin
- Phenobarbital
- Drospirenone
- Estradiol
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.