Ezetimibe and Erythromycin Interaction
Drug interaction information between Ezetimibe and Erythromycin.
Ezetimibe and Erythromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ezetimibe and Erythromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This antibiotic can stop your body from breaking down the other medicine properly, leading to higher levels in your blood.
FDA Label Information
Examples: Select azole anti-fungals (e.g., itraconazole, ketoconazole, posaconazole, and voriconazole), select macrolide antibiotics (e.g., erythromycin and clarithromycin, telithromycin), select HIV protease inhibitors (e.g., nelfinavir, ritonavir, and darunavir/ritonavir), select HCV protease inhibitors (e.g., boceprevir and telaprevir), cobicistat-containing products, and nefazodone.
Ezetimibe Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lefamulin moderate
Frequently Asked Questions
What SPL severity band is on file for Ezetimibe + Erythromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Ezetimibe's 25. In the minor band specifically: Ezetimibe has 13 (also Fenofibrate, Ketoconazole, Clarithromycin, Darunavir); Erythromycin has 53 (also Acetaminophen/Oxycodone, Alprazolam, Atorvastatin, Bromocriptine).
What mechanism field is on file for Ezetimibe and Erythromycin?
This antibiotic can stop your body from breaking down the other medicine properly, leading to higher levels in your blood.
Ezetimibe carries more major-labeled pairs than Erythromycin
SPL source-record counts only. This page's band is minor · classes on file: Ezetimibe (Cholesterol Absorption Inhibitor); Erythromycin (Macrolide Antibiotic).
Ezetimibe has 8 major-labeled pairs vs Erythromycin's 4. This page itself is in the minor band, not the major band.
8 major · 4 moderate · 13 minor · 25 total
- Other minor peers for Ezetimibe
- Fenofibrate
- Ketoconazole
- Clarithromycin
- Darunavir
4 major · 6 moderate · 53 minor · 63 total
- Other minor peers for Erythromycin
- Acetaminophen/Oxycodone
- Alprazolam
- Atorvastatin
- Bromocriptine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.