Ezetimibe and Amlodipine Interaction
Drug interaction information between Ezetimibe and Amlodipine.
Ezetimibe and Amlodipine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Ezetimibe and Amlodipine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amlodipine can increase the levels of the cholesterol medicine in your blood, which may lead to side effects.
FDA Label Information
For patients taking amiodarone, amlodipine, or ranolazine, do not exceed ezetimibe and simvastatin 10 mg/20 mg daily [see Dosage and Administration ( 2.3 )].
Ezetimibe Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Amlodipine Also Interacts With
- Simvastatin major
- Amlodipine/Benazepril major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir moderate
- Sildenafil minor
Frequently Asked Questions
What SPL severity band is on file for Ezetimibe + Amlodipine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ezetimibe has 25 labeled pairs on file vs Amlodipine's 15. In the major band specifically: Ezetimibe has 8 (also Diltiazem, Verapamil, Cyclosporine, Amiodarone); Amlodipine has 4 (also Simvastatin, Amlodipine/Benazepril, Ezetimibe/Simvastatin).
What mechanism field is on file for Ezetimibe and Amlodipine?
Amlodipine can increase the levels of the cholesterol medicine in your blood, which may lead to side effects.
Ezetimibe carries more major-labeled pairs than Amlodipine
SPL source-record counts only. This page's band is major · classes on file: Ezetimibe (Cholesterol Absorption Inhibitor); Amlodipine (Calcium Channel Blocker).
Ezetimibe has 8 major-labeled pairs vs Amlodipine's 4.
8 major · 4 moderate · 13 minor · 25 total
- Other major peers for Ezetimibe
- Diltiazem
- Verapamil
- Cyclosporine
- Amiodarone
4 major · 1 moderate · 10 minor · 15 total
- Other major peers for Amlodipine
- Simvastatin
- Amlodipine/Benazepril
- Ezetimibe/Simvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.