Ezetimibe and Ketoconazole Interaction
Drug interaction information between Ezetimibe and Ketoconazole.
Ezetimibe and Ketoconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ezetimibe and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medicine can slow down the way your body gets rid of the other drug, which may cause it to build up in your system.
FDA Label Information
Examples: Select azole anti-fungals (e.g., itraconazole, ketoconazole, posaconazole, and voriconazole), select macrolide antibiotics (e.g., erythromycin and clarithromycin, telithromycin), select HIV protease inhibitors (e.g., nelfinavir, ritonavir, and darunavir/ritonavir), select HCV protease inhibitors (e.g., boceprevir and telaprevir), cobicistat-containing products, and nefazodone.
Ezetimibe Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
What SPL severity band is on file for Ezetimibe + Ketoconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Ezetimibe's 25. In the minor band specifically: Ezetimibe has 13 (also Fenofibrate, Erythromycin, Clarithromycin, Darunavir); Ketoconazole has 85 (also Abiraterone, Acetaminophen/Oxycodone, Alosetron, Amphotericin B).
What mechanism field is on file for Ezetimibe and Ketoconazole?
This medicine can slow down the way your body gets rid of the other drug, which may cause it to build up in your system.
Ezetimibe carries more major-labeled pairs than Ketoconazole
SPL source-record counts only. This page's band is minor · classes on file: Ezetimibe (Cholesterol Absorption Inhibitor); Ketoconazole (Azole Antifungal).
Ezetimibe has 8 major-labeled pairs vs Ketoconazole's 6. This page itself is in the minor band, not the major band.
8 major · 4 moderate · 13 minor · 25 total
- Other minor peers for Ezetimibe
- Fenofibrate
- Erythromycin
- Clarithromycin
- Darunavir
6 major · 22 moderate · 85 minor · 113 total
- Other minor peers for Ketoconazole
- Abiraterone
- Acetaminophen/Oxycodone
- Alosetron
- Amphotericin B
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.