Ezetimibe and Clarithromycin Interaction
Drug interaction information between Ezetimibe and Clarithromycin.
Ezetimibe and Clarithromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ezetimibe and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medicine blocks the natural process your body uses to clear out the other drug, which could increase the risk of side effects.
FDA Label Information
Examples: Select azole anti-fungals (e.g., itraconazole, ketoconazole, posaconazole, and voriconazole), select macrolide antibiotics (e.g., erythromycin and clarithromycin, telithromycin), select HIV protease inhibitors (e.g., nelfinavir, ritonavir, and darunavir/ritonavir), select HCV protease inhibitors (e.g., boceprevir and telaprevir), cobicistat-containing products, and nefazodone.
Ezetimibe Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Ezetimibe + Clarithromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Ezetimibe's 25. In the minor band specifically: Ezetimibe has 13 (also Fenofibrate, Ketoconazole, Erythromycin, Darunavir); Clarithromycin has 30 (also Amlodipine, Lorazepam, Diltiazem, Erythromycin).
What mechanism field is on file for Ezetimibe and Clarithromycin?
This medicine blocks the natural process your body uses to clear out the other drug, which could increase the risk of side effects.
Clarithromycin carries more major-labeled pairs than Ezetimibe
SPL source-record counts only. This page's band is minor · classes on file: Ezetimibe (Cholesterol Absorption Inhibitor); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Ezetimibe's 8. This page itself is in the minor band, not the major band.
8 major · 4 moderate · 13 minor · 25 total
- Other minor peers for Ezetimibe
- Fenofibrate
- Ketoconazole
- Erythromycin
- Darunavir
16 major · 35 moderate · 30 minor · 81 total
- Other minor peers for Clarithromycin
- Amlodipine
- Lorazepam
- Diltiazem
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.