Ezetimibe and Fenofibrate Interaction
Drug interaction information between Ezetimibe and Fenofibrate.
Ezetimibe and Fenofibrate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ezetimibe and Fenofibrate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs increase the amount of cholesterol in your bile, which can lead to the formation of gallstones.
FDA Label Information
( 7.3 ) Fenofibrates : Combination increases exposure of ezetimibe. If cholelithiasis is suspected in a patient receiving ezetimibe and a fenofibrate, gallbladder studies are indicated and alternative lipid-lowering therapy should be considered. Fenofibrates Clinical Impact: Both ezetimibe and fenofibrates may increase cholesterol excretion into the bile, leading to cholelithiasis.
Ezetimibe Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
Fenofibrate Also Interacts With
- Cyclosporine moderate
- Colchicine moderate
- Bempedoic Acid moderate
- Bempedoic Acid/Ezetimibe moderate
- Ezetimibe/Simvastatin minor
Frequently Asked Questions
What SPL severity band is on file for Ezetimibe + Fenofibrate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ezetimibe has 25 labeled pairs on file vs Fenofibrate's 9. In the minor band specifically: Ezetimibe has 13 (also Ketoconazole, Erythromycin, Clarithromycin, Darunavir); Fenofibrate has 5 (also Ezetimibe/Simvastatin, Rosuvastatin, Rosuvastatin/Ezetimibe, Simvastatin).
What mechanism field is on file for Ezetimibe and Fenofibrate?
Both drugs increase the amount of cholesterol in your bile, which can lead to the formation of gallstones.
Ezetimibe carries more major-labeled pairs than Fenofibrate
SPL source-record counts only. This page's band is minor · classes on file: Ezetimibe (Cholesterol Absorption Inhibitor); Fenofibrate (Fibrate).
Ezetimibe has 8 major-labeled pairs vs Fenofibrate's 0. This page itself is in the minor band, not the major band.
8 major · 4 moderate · 13 minor · 25 total
- Other minor peers for Ezetimibe
- Ketoconazole
- Erythromycin
- Clarithromycin
- Darunavir
0 major · 4 moderate · 5 minor · 9 total
- Other minor peers for Fenofibrate
- Ezetimibe/Simvastatin
- Rosuvastatin
- Rosuvastatin/Ezetimibe
- Simvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.