Eplerenone and Lisinopril Interaction
Drug interaction information between Eplerenone and Lisinopril.
Eplerenone and Lisinopril have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Eplerenone and Lisinopril. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medicines both stop the body from flushing out potassium. Using them at the same time can cause too much potassium to stay in your blood.
FDA Label Information
Use of lisinopril with potassium-sparing diuretics (e.g., spironolactone, eplerenone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium.
Eplerenone Also Interacts With
- Fluconazole major
- Verapamil major
- Erythromycin major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
Lisinopril Also Interacts With
- Hydrochlorothiazide major
- Aliskiren major
- Losartan minor
- Spironolactone minor
- Propranolol minor
Frequently Asked Questions
What SPL severity band is on file for Eplerenone + Lisinopril?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lisinopril has 15 labeled pairs on file vs Eplerenone's 12. In the minor band specifically: Eplerenone has 7 (also Lithium, Hydrochlorothiazide, Hydrochlorothiazide, Hydrochlorothiazide); Lisinopril has 13 (also Losartan, Spironolactone, Propranolol, Lithium).
What mechanism field is on file for Eplerenone and Lisinopril?
These medicines both stop the body from flushing out potassium. Using them at the same time can cause too much potassium to stay in your blood.
Eplerenone carries more major-labeled pairs than Lisinopril
SPL source-record counts only. This page's band is minor · classes on file: Eplerenone (Aldosterone Antagonist); Lisinopril (ACE Inhibitor).
Eplerenone has 5 major-labeled pairs vs Lisinopril's 2. This page itself is in the minor band, not the major band.
5 major · 0 moderate · 7 minor · 12 total
- Other minor peers for Eplerenone
- Lithium
- Hydrochlorothiazide
- Hydrochlorothiazide
- Hydrochlorothiazide
2 major · 0 moderate · 13 minor · 15 total
- Other minor peers for Lisinopril
- Losartan
- Spironolactone
- Propranolol
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.