Lisinopril and Hydrochlorothiazide Interaction
Drug interaction information between Lisinopril and Hydrochlorothiazide.
Lisinopril and Hydrochlorothiazide have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Lisinopril and Hydrochlorothiazide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs work in different ways to lower blood pressure and do not interfere with how the body breaks each other down.
FDA Label Information
Monitor blood pressure, renal function, and electrolytes in patients on lisinopril and hydrochlorothiazide tablets and other agents that affect the RAS. Do not coadminister aliskiren with lisinopril and hydrochlorothiazide tablets in patients with diabetes. No meaningful clinically important pharmacokinetic interactions occurred when lisinopril was used concomitantly with propranolol, digoxin, or hydrochlorothiazide.
Lisinopril Also Interacts With
- Aliskiren major
- Losartan minor
- Spironolactone minor
- Propranolol minor
- Lithium minor
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Hydrochlorothiazide/Triamterene major
- Olmesartan moderate
- Losartan minor
- Spironolactone minor
Frequently Asked Questions
What SPL severity band is on file for Lisinopril + Hydrochlorothiazide?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Hydrochlorothiazide has 31 labeled pairs on file vs Lisinopril's 15. In the major band specifically: Lisinopril has 2 (also Aliskiren); Hydrochlorothiazide has 3 (also Aliskiren, Hydrochlorothiazide).
What mechanism field is on file for Lisinopril and Hydrochlorothiazide?
These drugs work in different ways to lower blood pressure and do not interfere with how the body breaks each other down.
Hydrochlorothiazide carries more major-labeled pairs than Lisinopril
SPL source-record counts only. This page's band is major · classes on file: Lisinopril (ACE Inhibitor); Hydrochlorothiazide (Thiazide Diuretic).
Hydrochlorothiazide has 3 major-labeled pairs vs Lisinopril's 2.
3 major · 1 moderate · 27 minor · 31 total
- Other major peers for Hydrochlorothiazide
- Aliskiren
- Hydrochlorothiazide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.