Eplerenone and Nirmatrelvir/Ritonavir Interaction
Drug interaction information between Eplerenone and Nirmatrelvir/Ritonavir.
Eplerenone and Nirmatrelvir/Ritonavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Eplerenone and Nirmatrelvir/Ritonavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Nirmatrelvir/ritonavir raises the levels of eplerenone in your blood by slowing its breakdown. This can cause your potassium levels to become dangerously high.
FDA Label Information
Cardiovascular agents eplerenone ↑ eplerenone Co-administration with eplerenone is contraindicated due to potential for hyperkalemia [see Contraindications (4) ] .
Eplerenone Also Interacts With
- Fluconazole major
- Verapamil major
- Erythromycin major
- Itraconazole major
- Lithium minor
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Frequently Asked Questions
What SPL severity band is on file for Eplerenone + Nirmatrelvir/Ritonavir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Eplerenone's 12. In the major band specifically: Eplerenone has 5 (also Fluconazole, Verapamil, Erythromycin, Itraconazole); Nirmatrelvir/Ritonavir has 23 (also Simvastatin, Lovastatin, Sildenafil, Carbamazepine).
What mechanism field is on file for Eplerenone and Nirmatrelvir/Ritonavir?
Nirmatrelvir/ritonavir raises the levels of eplerenone in your blood by slowing its breakdown. This can cause your potassium levels to become dangerously high.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Eplerenone
SPL source-record counts only. This page's band is major · classes on file: Eplerenone (Aldosterone Antagonist); Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Eplerenone's 5.
5 major · 0 moderate · 7 minor · 12 total
- Other major peers for Eplerenone
- Fluconazole
- Verapamil
- Erythromycin
- Itraconazole
23 major · 30 moderate · 33 minor · 86 total
- Other major peers for Nirmatrelvir/Ritonavir
- Simvastatin
- Lovastatin
- Sildenafil
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.