Lisinopril and Propranolol Interaction
Drug interaction information between Lisinopril and Propranolol.
Lisinopril and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lisinopril and Propranolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs do not change how the body absorbs or breaks down one another.
FDA Label Information
No meaningful clinically important pharmacokinetic interactions occurred when lisinopril was used concomitantly with propranolol, digoxin, or hydrochlorothiazide.
Lisinopril Also Interacts With
- Hydrochlorothiazide major
- Aliskiren major
- Losartan minor
- Spironolactone minor
- Lithium minor
Frequently Asked Questions
What SPL severity band is on file for Lisinopril + Propranolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propranolol has 44 labeled pairs on file vs Lisinopril's 15. In the minor band specifically: Lisinopril has 13 (also Losartan, Spironolactone, Lithium, Amiloride); Propranolol has 44 (also Clonidine, Diltiazem, Warfarin, Verapamil).
What mechanism field is on file for Lisinopril and Propranolol?
These drugs do not change how the body absorbs or breaks down one another.
Lisinopril carries more major-labeled pairs than Propranolol
SPL source-record counts only. This page's band is minor · classes on file: Lisinopril (ACE Inhibitor); Propranolol (Non-Selective Beta-Blocker).
Lisinopril has 2 major-labeled pairs vs Propranolol's 0. This page itself is in the minor band, not the major band.
2 major · 0 moderate · 13 minor · 15 total
- Other minor peers for Lisinopril
- Losartan
- Spironolactone
- Lithium
- Amiloride
0 major · 0 moderate · 44 minor · 44 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.