Eplerenone and Fluconazole Interaction
Drug interaction information between Eplerenone and Fluconazole.
Eplerenone and Fluconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Eplerenone and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole blocks the enzyme that clears eplerenone from your body, which can lead to higher levels of the drug in your blood.
FDA Label Information
7 DRUG INTERACTIONS • CYP3A Inhibitors: In post-MI HFrEF patients, do not exceed 25 mg once daily when used with moderate CYP3A inhibitors (e.g., verapamil, erythromycin, saquinavir, fluconazole).
Eplerenone Also Interacts With
- Verapamil major
- Erythromycin major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Lithium minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Atorvastatin moderate
- Simvastatin moderate
- Carbamazepine moderate
Frequently Asked Questions
What SPL severity band is on file for Eplerenone + Fluconazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Eplerenone's 12. In the major band specifically: Eplerenone has 5 (also Verapamil, Erythromycin, Itraconazole, Nirmatrelvir/Ritonavir); Fluconazole has 3 (also Pimozide, Clarithromycin).
What mechanism field is on file for Eplerenone and Fluconazole?
Fluconazole blocks the enzyme that clears eplerenone from your body, which can lead to higher levels of the drug in your blood.
Eplerenone carries more major-labeled pairs than Fluconazole
SPL source-record counts only. This page's band is major · classes on file: Eplerenone (Aldosterone Antagonist); Fluconazole (Azole Antifungal).
Eplerenone has 5 major-labeled pairs vs Fluconazole's 3.
5 major · 0 moderate · 7 minor · 12 total
- Other major peers for Eplerenone
- Verapamil
- Erythromycin
- Itraconazole
- Nirmatrelvir/Ritonavir
3 major · 7 moderate · 57 minor · 67 total
- Other major peers for Fluconazole
- Pimozide
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.