What the FDA labels say about taking them together
Eplerenone and fluconazole
Eplerenone's FDA label of June 23, 2025 names fluconazole in its drug interactions section; the fluconazole labels PlainMeds reads (2) do not name eplerenone. The eplerenone label: “CYP3A Inhibitors: In post-MI HFrEF patients, do not exceed 25 mg once daily when used with moderate CYP3A inhibitors.”
Check it at the source: the eplerenone FDA label on DailyMed (effective June 23, 2025, Viatris Specialty LLC); the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the eplerenone label say about fluconazole?
Eplerenone label, drug interactionsCYP3A Inhibitors: In post-MI HFrEF patients, do not exceed 25 mg once daily when used with moderate CYP3A inhibitors (e.g., verapamil, erythromycin, saquinavir, fluconazole).
Source: FDA drug label (Inspra), NDA021437 (Upjohn), as published by Viatris Specialty LLC, effective June 23, 2025 (SPL set 1a52bedc-8e2c-4116-a296-a87770676b4a), via openFDA; the full label on DailyMed
What does the fluconazole label say about eplerenone?
Fluconazole's label (effective April 7, 2026) and its 1 other brand-application label do not name eplerenone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Eplerenone | Fluconazole | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure | Fungal infections, Urinary tract infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.308 per tablet 25 mg tablet | $0.380 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once