Eplerenone and Fluconazole Interaction
Drug interaction information between Eplerenone and Fluconazole.
Eplerenone and Fluconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Eplerenone and Fluconazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Fluconazole blocks the enzyme that clears eplerenone from your body, which can lead to higher levels of the drug in your blood.
What To Do
Your doctor should lower your eplerenone dose to a maximum of 25 mg once daily.
FDA Label Information
7 DRUG INTERACTIONS • CYP3A Inhibitors: In post-MI HFrEF patients, do not exceed 25 mg once daily when used with moderate CYP3A inhibitors (e.g., verapamil, erythromycin, saquinavir, fluconazole).
Eplerenone Also Interacts With
- Verapamil major
- Erythromycin major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Lithium minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Atorvastatin moderate
- Simvastatin moderate
- Carbamazepine moderate
Frequently Asked Questions
Can I take Eplerenone and Fluconazole together?
This is a major interaction. Your doctor should lower your eplerenone dose to a maximum of 25 mg once daily.
How serious is the interaction between Eplerenone and Fluconazole?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Eplerenone and Fluconazole interact?
Fluconazole blocks the enzyme that clears eplerenone from your body, which can lead to higher levels of the drug in your blood.
Understanding the Eplerenone and Fluconazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Eplerenone belongs to the Aldosterone Antagonist class and Fluconazole belongs to the Azole Antifungal class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Fluconazole blocks the enzyme that clears eplerenone from your body, which can lead to higher levels of the drug in your blood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Eplerenone has 12 total documented interactions on file in this dataset, and Fluconazole has 67. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should lower your eplerenone dose to a maximum of 25 mg once daily. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Eplerenone or Fluconazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.