What the FDA labels say about taking them together
Eplerenone and lithium
Eplerenone's FDA label of June 23, 2025 names lithium in its drug interactions section; the lithium labels PlainMeds reads (4) do not name eplerenone. The eplerenone label: “Lithium toxicity has been reported in patients receiving lithium concomitantly with diuretics and ACE inhibitors.”
Check it at the source: the eplerenone FDA label on DailyMed (effective June 23, 2025, Viatris Specialty LLC); the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the eplerenone label say about lithium?
Eplerenone label, drug interactionsLithium toxicity has been reported in patients receiving lithium concomitantly with diuretics and ACE inhibitors.
Source: FDA drug label (Inspra), NDA021437 (Upjohn), as published by Viatris Specialty LLC, effective June 23, 2025 (SPL set 1a52bedc-8e2c-4116-a296-a87770676b4a), via openFDA; the full label on DailyMed
What does the lithium label say about eplerenone?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name eplerenone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Eplerenone | Lithium | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure | Bipolar disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.308 per tablet 25 mg tablet | $0.104 per capsule 300 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once