Eplerenone and Lithium Interaction
Drug interaction information between Eplerenone and Lithium.
Eplerenone and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Eplerenone and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This drug may cause your body to hold onto lithium, which can lead to toxic levels of lithium in your blood.
FDA Label Information
7.3 Lithium A drug interaction study of eplerenone with lithium has not been conducted. Lithium toxicity has been reported in patients receiving lithium concomitantly with diuretics and ACE inhibitors. Serum lithium levels should be monitored frequently if INSPRA is administered concomitantly with lithium.
Eplerenone Also Interacts With
- Fluconazole major
- Verapamil major
- Erythromycin major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Eplerenone + Lithium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Eplerenone's 12. In the minor band specifically: Eplerenone has 7 (also Hydrochlorothiazide, Hydrochlorothiazide, Hydrochlorothiazide, Lisinopril); Lithium has 65 (also Aripiprazole, Asenapine, Canagliflozin, Candesartan).
What mechanism field is on file for Eplerenone and Lithium?
This drug may cause your body to hold onto lithium, which can lead to toxic levels of lithium in your blood.
Eplerenone carries more major-labeled pairs than Lithium
SPL source-record counts only. This page's band is minor · classes on file: Eplerenone (Aldosterone Antagonist); Lithium (Mood Stabilizer).
Eplerenone has 5 major-labeled pairs vs Lithium's 2. This page itself is in the minor band, not the major band.
5 major · 0 moderate · 7 minor · 12 total
- Other minor peers for Eplerenone
- Hydrochlorothiazide
- Hydrochlorothiazide
- Hydrochlorothiazide
- Lisinopril
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Asenapine
- Canagliflozin
- Candesartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.