Lisinopril and Aliskiren Interaction
Drug interaction information between Lisinopril and Aliskiren.
Lisinopril and Aliskiren have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Lisinopril and Aliskiren. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both medicines target the same body system to lower blood pressure, which can lead to dangerously low blood pressure or kidney damage.
FDA Label Information
Dual Blockade of the Renin-Angiotensin System (RAS): Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or direct renin inhibitors (such as aliskiren) is associated with increased risk of hypotension, syncope, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Do not coadminister aliskiren with lisinopril and hydrochlorothiazide tablets in patients with diabetes. Avoid use of aliskiren with PRINZIDE in patients with renal impairment (GFR <60 ml/min).
Lisinopril Also Interacts With
- Hydrochlorothiazide major
- Losartan minor
- Spironolactone minor
- Propranolol minor
- Lithium minor
Aliskiren Also Interacts With
- Amlodipine/Benazepril major
- Amlodipine/Valsartan major
- Azilsartan major
- Benazepril major
- Candesartan major
Frequently Asked Questions
What SPL severity band is on file for Lisinopril + Aliskiren?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aliskiren has 28 labeled pairs on file vs Lisinopril's 15. In the major band specifically: Lisinopril has 2 (also Hydrochlorothiazide); Aliskiren has 22 (also Amlodipine/Benazepril, Amlodipine/Valsartan, Azilsartan, Benazepril).
What mechanism field is on file for Lisinopril and Aliskiren?
Both medicines target the same body system to lower blood pressure, which can lead to dangerously low blood pressure or kidney damage.
Aliskiren carries more major-labeled pairs than Lisinopril
SPL source-record counts only. This page's band is major · classes on file: Lisinopril (ACE Inhibitor); Aliskiren (Direct Renin Inhibitor).
Aliskiren has 22 major-labeled pairs vs Lisinopril's 2.
2 major · 0 moderate · 13 minor · 15 total
- Other major peers for Lisinopril
- Hydrochlorothiazide
22 major · 3 moderate · 3 minor · 28 total
- Other major peers for Aliskiren
- Amlodipine/Benazepril
- Amlodipine/Valsartan
- Azilsartan
- Benazepril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.