eplerenone vs lisinopril
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Side-by-side comparison of eplerenone and lisinopril. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Use of lisinopril with potassium-sparing diuretics (e.g., spironolactone, eplerenone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium.
Inspra
Prinivil, Zestril
Eplerenone (Inspra) helps you live longer if you have heart failure after a heart attack. It also lowers blood pressure if you have high blood pressure.
No summary available.
Eplerenone is used to help people with heart failure who have had a heart attack live longer. It is also used to treat high blood pressure in adults. Lowering blood pressure helps reduce the risk of strokes and heart attacks.
Information not available.
Eplerenone blocks a hormone called aldosterone in your body. Aldosterone can cause your body to hold onto too much salt and water, which can raise blood pressure and worsen heart failure. By blocking aldosterone, eplerenone helps lower blood pressure and reduce strain on the heart.
Information not available.
- • High potassium levels in your blood
- • Increased creatinine levels
- • Dizziness
- • Headache
- • Cough
- • Feeling tired
- • Diarrhea
- Dyspnoea 1,083
- Cardiac Failure 939
- Acute Kidney Injury 905
- Hypotension 859
- Fatigue 659
- Fatigue 19,346
- Nausea 17,996
- Diarrhoea 16,771
- Dyspnoea 13,650
- Pain 13,303
Eplerenone can cause high potassium levels in your blood, which can be dangerous. Your doctor will check your potassium levels before you start taking eplerenone and regularly while you are taking it. People with kidney problems, diabetes, or who take certain other medicines are at higher risk.
No specific warnings noted.
It is not known if eplerenone can harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if eplerenone passes into breast milk. Talk to your doctor about the best way to feed your baby if you are taking eplerenone.
No pregnancy information available.
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How to Read This eplerenone vs lisinopril Comparison
eplerenone is classified in the Aldosterone Antagonist drug class, while lisinopril sits within the ACE Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, eplerenone has 4,445 submissions while lisinopril has 81,066. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these medicines both stop the body from flushing out potassium. using them at the same time can cause too much potassium to stay in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for eplerenone or lisinopril.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.