Lisinopril and Losartan Interaction
Drug interaction information between Lisinopril and Losartan.
Lisinopril and Losartan have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lisinopril and Losartan. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Using these two blood pressure drugs together can overwork the kidneys and cause potassium to build up to unsafe levels.
What To Do
This combination is usually avoided because it increases the risk of kidney injury without providing extra health benefits.
FDA Label Information
The VA NEPHRON trial enrolled 1448 patients with type 2 diabetes, elevated urinary-albumin-to-creatinine ratio, and decreased estimated glomerular filtration rate (GFR 30 to 89.9 ml/min), randomized them to lisinopril or placebo on a background of losartan therapy and followed them for a median of 2.2 years. Patients receiving the combination of losartan and lisinopril did not obtain any additional benefit compared to monotherapy for the combined endpoint of decline in GFR, end state renal disease, or death, but experienced an increased incidence of hyperkalemia and acute kidney injury...
Lisinopril Also Interacts With
- Hydrochlorothiazide major
- Aliskiren major
- Spironolactone minor
- Propranolol minor
- Lithium minor
Losartan Also Interacts With
- Aliskiren major
- Lithium moderate
- Fluconazole minor
- Glecaprevir/Pibrentasvir minor
- Hydrochlorothiazide minor
Frequently Asked Questions
Can I take Lisinopril and Losartan together?
This is a minor interaction. This combination is usually avoided because it increases the risk of kidney injury without providing extra health benefits.
How serious is the interaction between Lisinopril and Losartan?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Lisinopril and Losartan interact?
Using these two blood pressure drugs together can overwork the kidneys and cause potassium to build up to unsafe levels.
Understanding the Lisinopril and Losartan Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Lisinopril belongs to the ACE Inhibitor class and Losartan belongs to the Angiotensin II Receptor Blocker (ARB) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Using these two blood pressure drugs together can overwork the kidneys and cause potassium to build up to unsafe levels. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Lisinopril has 15 total documented interactions on file in this dataset, and Losartan has 10. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: This combination is usually avoided because it increases the risk of kidney injury without providing extra health benefits. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Lisinopril or Losartan based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.