What the FDA labels say about taking them together
Lisinopril and lithium
Lisinopril's FDA label of January 2, 2025 names lithium in its drug interactions section; the lithium labels PlainMeds reads (4) do not name lisinopril. The lisinopril label: “Symptoms of lithium toxicity.”
Check it at the source: the lisinopril FDA label on DailyMed (effective January 2, 2025, Upsher-Smith Laboratories, LLC); the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the lisinopril label say about lithium?
Lisinopril label, drug interactionsIncreased risk of renal impairment, hypotension and hyperkalemia ( 7.4 ) Lithium: Symptoms of lithium toxicity ( 7.5 ) Gold:
Qbrelis label (Azurity Pharmaceuticals, Inc., December 16, 2025), drug interactionsSymptoms of lithium toxicity ( 7.5 ).
Source: FDA drug label (Qbrelis, NDA208401), Azurity Pharmaceuticals, Inc., effective December 16, 2025 (SPL set 9f6e4e57-a489-4b36-b093-b93865d3717c), via openFDA
Source: FDA drug label (Zestril), NDA019777 (Twi Pharms), as published by Upsher-Smith Laboratories, LLC, effective January 2, 2025 (SPL set 838c2d78-d2d8-4981-9ec9-e50ef9e1a5d8), via openFDA; the full label on DailyMed
What does the lithium label say about lisinopril?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name lisinopril in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lisinopril | Lithium | |
|---|---|---|
| Labeled for | High blood pressure, Heart attack and coronary artery disease, Heart failure | Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0254 per tablet 20 mg tablet | $0.104 per capsule 300 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once