Eplerenone and Erythromycin Interaction
Drug interaction information between Eplerenone and Erythromycin.
Eplerenone and Erythromycin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Eplerenone and Erythromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Erythromycin blocks the proteins that break down eplerenone, leading to more of the drug staying in your body.
FDA Label Information
7 DRUG INTERACTIONS • CYP3A Inhibitors: In post-MI HFrEF patients, do not exceed 25 mg once daily when used with moderate CYP3A inhibitors (e.g., verapamil, erythromycin, saquinavir, fluconazole).
Eplerenone Also Interacts With
- Fluconazole major
- Verapamil major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Lithium minor
Erythromycin Also Interacts With
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lefamulin moderate
- Lovastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Eplerenone + Erythromycin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Eplerenone's 12. In the major band specifically: Eplerenone has 5 (also Fluconazole, Verapamil, Itraconazole, Nirmatrelvir/Ritonavir); Erythromycin has 4 (also Pitavastatin, Risperidone, Sildenafil).
What mechanism field is on file for Eplerenone and Erythromycin?
Erythromycin blocks the proteins that break down eplerenone, leading to more of the drug staying in your body.
Eplerenone carries more major-labeled pairs than Erythromycin
SPL source-record counts only. This page's band is major · classes on file: Eplerenone (Aldosterone Antagonist); Erythromycin (Macrolide Antibiotic).
Eplerenone has 5 major-labeled pairs vs Erythromycin's 4.
5 major · 0 moderate · 7 minor · 12 total
- Other major peers for Eplerenone
- Fluconazole
- Verapamil
- Itraconazole
- Nirmatrelvir/Ritonavir
4 major · 6 moderate · 53 minor · 63 total
- Other major peers for Erythromycin
- Pitavastatin
- Risperidone
- Sildenafil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.