Emtricitabine/Tenofovir and Ledipasvir/Sofosbuvir Interaction
Drug interaction information between Emtricitabine/Tenofovir and Ledipasvir/Sofosbuvir.
Emtricitabine/Tenofovir and Ledipasvir/Sofosbuvir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Emtricitabine/Tenofovir and Ledipasvir/Sofosbuvir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these drugs together can increase the amount of tenofovir that stays in your body. This can make side effects from the medication more likely to happen.
FDA Label Information
7.3 Hepatitis C Antiviral Agents Coadministration of tenofovir disoproxil fumarate and HARVONI ® (ledipasvir/sofosbuvir) has been shown to increase tenofovir exposure [see Clinical Pharmacology (12.3) ] . In patients receiving TRUVADA concomitantly with HARVONI without an HIV-1 protease inhibitor/ritonavir or an HIV-1 protease inhibitor/cobicistat combination, monitor for adverse reactions associated with tenofovir disoproxil fumarate. In patients receiving TRUVADA concomitantly with HARVONI and an HIV-1 protease inhibitor/ritonavir or an HIV-1 protease inhibitor/cobicistat combination,...
Emtricitabine/Tenofovir Also Interacts With
- Valacyclovir minor
- Acyclovir minor
- Gentamicin minor
- Tenofovir Disoproxil minor
- Darunavir minor
Ledipasvir/Sofosbuvir Also Interacts With
- Atorvastatin moderate
- Rifampin moderate
- Amiodarone moderate
- Rosuvastatin moderate
- Rosuvastatin/Ezetimibe moderate
Frequently Asked Questions
What SPL severity band is on file for Emtricitabine/Tenofovir + Ledipasvir/Sofosbuvir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ledipasvir/Sofosbuvir has 22 labeled pairs on file vs Emtricitabine/Tenofovir's 9. In the minor band specifically: Emtricitabine/Tenofovir has 9 (also Valacyclovir, Acyclovir, Gentamicin, Tenofovir Disoproxil); Ledipasvir/Sofosbuvir has 17 (also Omeprazole, Pravastatin, Warfarin, Verapamil).
What mechanism field is on file for Emtricitabine/Tenofovir and Ledipasvir/Sofosbuvir?
Using these drugs together can increase the amount of tenofovir that stays in your body. This can make side effects from the medication more likely to happen.
Ledipasvir/Sofosbuvir's labeled portfolio outnumbers Emtricitabine/Tenofovir
SPL source-record counts only. This page's band is minor · classes on file: Emtricitabine/Tenofovir (NRTI Combination (HIV PrEP)); Ledipasvir/Sofosbuvir (NS5A/NS5B Inhibitor (HCV)).
0 major · 0 moderate · 9 minor · 9 total
- Other minor peers for Emtricitabine/Tenofovir
- Valacyclovir
- Acyclovir
- Gentamicin
- Tenofovir Disoproxil
0 major · 5 moderate · 17 minor · 22 total
- Other minor peers for Ledipasvir/Sofosbuvir
- Omeprazole
- Pravastatin
- Warfarin
- Verapamil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.