Emtricitabine/Tenofovir and Valacyclovir Interaction
Drug interaction information between Emtricitabine/Tenofovir and Valacyclovir.
Emtricitabine/Tenofovir and Valacyclovir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Emtricitabine/Tenofovir and Valacyclovir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs are removed from the body through the kidneys, and taking them together can increase the risk of kidney damage.
FDA Label Information
Some examples include, but are not limited to, acyclovir, adefovir dipivoxil, cidofovir, ganciclovir, valacyclovir, valganciclovir, aminoglycosides (e.g., gentamicin), and high-dose or multiple NSAIDs [see Warnings and Precautions (5.3) ] .
Emtricitabine/Tenofovir Also Interacts With
- Acyclovir minor
- Gentamicin minor
- Tenofovir Disoproxil minor
- Darunavir minor
- Ledipasvir/Sofosbuvir minor
Valacyclovir Also Interacts With
View all Valacyclovir interactions →Frequently Asked Questions
What SPL severity band is on file for Emtricitabine/Tenofovir + Valacyclovir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Emtricitabine/Tenofovir has 9 labeled pairs on file vs Valacyclovir's 3. In the minor band specifically: Emtricitabine/Tenofovir has 9 (also Acyclovir, Gentamicin, Tenofovir Disoproxil, Darunavir); Valacyclovir has 3 (also Bictegravir, Tenofovir Disoproxil).
What mechanism field is on file for Emtricitabine/Tenofovir and Valacyclovir?
Both of these drugs are removed from the body through the kidneys, and taking them together can increase the risk of kidney damage.
Emtricitabine/Tenofovir's labeled portfolio outnumbers Valacyclovir
SPL source-record counts only. This page's band is minor · classes on file: Emtricitabine/Tenofovir (NRTI Combination (HIV PrEP)); Valacyclovir (Antiviral).
0 major · 0 moderate · 9 minor · 9 total
- Other minor peers for Emtricitabine/Tenofovir
- Acyclovir
- Gentamicin
- Tenofovir Disoproxil
- Darunavir
0 major · 0 moderate · 3 minor · 3 total
- Other minor peers for Valacyclovir
- Bictegravir
- Tenofovir Disoproxil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.