Emtricitabine/Tenofovir and Darunavir Interaction
Drug interaction information between Emtricitabine/Tenofovir and Darunavir.
Emtricitabine/Tenofovir and Darunavir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Emtricitabine/Tenofovir and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination can cause the level of tenofovir in your blood to rise. Higher levels of the drug can increase your risk of experiencing side effects.
FDA Label Information
Coadministration of TRUVADA with atazanavir and ritonavir, darunavir and ritonavir, or lopinavir/ritonavir increases tenofovir concentrations. Lopinavir/ritonavir, atazanavir coadministered with ritonavir, and darunavir coadministered with ritonavir have been shown to increase tenofovir concentrations [see Clinical Pharmacology (12.3) ] . Patients receiving TRUVADA concomitantly with lopinavir/ritonavir, ritonavir-boosted atazanavir, or ritonavir-boosted darunavir should be monitored for tenofovir disoproxil fumarate-associated adverse reactions.
Emtricitabine/Tenofovir Also Interacts With
- Valacyclovir minor
- Acyclovir minor
- Gentamicin minor
- Tenofovir Disoproxil minor
- Ledipasvir/Sofosbuvir minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Emtricitabine/Tenofovir + Darunavir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Emtricitabine/Tenofovir's 9. In the minor band specifically: Emtricitabine/Tenofovir has 9 (also Valacyclovir, Acyclovir, Gentamicin, Tenofovir Disoproxil); Darunavir has 70 (also Amlodipine, Metoprolol, Sertraline, Rosuvastatin).
What mechanism field is on file for Emtricitabine/Tenofovir and Darunavir?
This combination can cause the level of tenofovir in your blood to rise. Higher levels of the drug can increase your risk of experiencing side effects.
Darunavir carries more major-labeled pairs than Emtricitabine/Tenofovir
SPL source-record counts only. This page's band is minor · classes on file: Emtricitabine/Tenofovir (NRTI Combination (HIV PrEP)); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Emtricitabine/Tenofovir's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 9 minor · 9 total
- Other minor peers for Emtricitabine/Tenofovir
- Valacyclovir
- Acyclovir
- Gentamicin
- Tenofovir Disoproxil
15 major · 16 moderate · 70 minor · 101 total
- Other minor peers for Darunavir
- Amlodipine
- Metoprolol
- Sertraline
- Rosuvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.