Emtricitabine/Tenofovir and Gentamicin Interaction
Drug interaction information between Emtricitabine/Tenofovir and Gentamicin.
Emtricitabine/Tenofovir and Gentamicin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Emtricitabine/Tenofovir and Gentamicin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs are removed from the body through the kidneys. Taking them at the same time can increase the risk of kidney damage or raise drug levels in your blood.
FDA Label Information
Some examples include, but are not limited to, acyclovir, adefovir dipivoxil, cidofovir, ganciclovir, valacyclovir, valganciclovir, aminoglycosides (e.g., gentamicin), and high-dose or multiple NSAIDs [see Warnings and Precautions (5.3) ] .
Emtricitabine/Tenofovir Also Interacts With
- Valacyclovir minor
- Acyclovir minor
- Tenofovir Disoproxil minor
- Darunavir minor
- Ledipasvir/Sofosbuvir minor
Gentamicin Also Interacts With
- Cidofovir major
- Bictegravir/Emtricitabine/Tenofovir minor
- Digoxin minor
- Perindopril minor
- Piperacillin/Tazobactam minor
Frequently Asked Questions
What SPL severity band is on file for Emtricitabine/Tenofovir + Gentamicin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Emtricitabine/Tenofovir has 9 labeled pairs on file vs Gentamicin's 7. In the minor band specifically: Emtricitabine/Tenofovir has 9 (also Valacyclovir, Acyclovir, Tenofovir Disoproxil, Darunavir); Gentamicin has 6 (also Bictegravir, Digoxin, Perindopril, Piperacillin/Tazobactam).
What mechanism field is on file for Emtricitabine/Tenofovir and Gentamicin?
Both of these drugs are removed from the body through the kidneys. Taking them at the same time can increase the risk of kidney damage or raise drug levels in your blood.
Gentamicin carries more major-labeled pairs than Emtricitabine/Tenofovir
SPL source-record counts only. This page's band is minor · classes on file: Emtricitabine/Tenofovir (NRTI Combination (HIV PrEP)); Gentamicin (Aminoglycoside Antibiotic).
Gentamicin has 1 major-labeled pair vs Emtricitabine/Tenofovir's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 9 minor · 9 total
- Other minor peers for Emtricitabine/Tenofovir
- Valacyclovir
- Acyclovir
- Tenofovir Disoproxil
- Darunavir
1 major · 0 moderate · 6 minor · 7 total
- Other minor peers for Gentamicin
- Bictegravir
- Digoxin
- Perindopril
- Piperacillin/Tazobactam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.