Emtricitabine/Tenofovir and Tenofovir Disoproxil Interaction
Drug interaction information between Emtricitabine/Tenofovir and Tenofovir Disoproxil.
Emtricitabine/Tenofovir and Tenofovir Disoproxil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Emtricitabine/Tenofovir and Tenofovir Disoproxil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications contain the same active ingredient. Taking both at once can lead to having too much of the medicine in your body.
FDA Label Information
Drug interaction trials have been conducted with emtricitabine and tenofovir disoproxil fumarate, the components of TRUVADA. This section describes clinically relevant drug interactions observed with emtricitabine and tenofovir disoproxil fumarate [see Clinical Pharmacology (12.3) ] . Didanosine: Tenofovir disoproxil fumarate increases didanosine concentrations.
Emtricitabine/Tenofovir Also Interacts With
- Valacyclovir minor
- Acyclovir minor
- Gentamicin minor
- Darunavir minor
- Ledipasvir/Sofosbuvir minor
Tenofovir Disoproxil Also Interacts With
- Itraconazole moderate
- Valacyclovir minor
- Acyclovir minor
- Gentamicin minor
- Darunavir minor
Frequently Asked Questions
What SPL severity band is on file for Emtricitabine/Tenofovir + Tenofovir Disoproxil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tenofovir Disoproxil has 14 labeled pairs on file vs Emtricitabine/Tenofovir's 9. In the minor band specifically: Emtricitabine/Tenofovir has 9 (also Valacyclovir, Acyclovir, Gentamicin, Darunavir); Tenofovir Disoproxil has 13 (also Valacyclovir, Acyclovir, Gentamicin, Darunavir).
What mechanism field is on file for Emtricitabine/Tenofovir and Tenofovir Disoproxil?
These medications contain the same active ingredient. Taking both at once can lead to having too much of the medicine in your body.
Tenofovir Disoproxil's labeled portfolio outnumbers Emtricitabine/Tenofovir
SPL source-record counts only. This page's band is minor · classes on file: Emtricitabine/Tenofovir (NRTI Combination (HIV PrEP)); Tenofovir Disoproxil (Nucleotide Reverse Transcriptase Inhibitor).
0 major · 0 moderate · 9 minor · 9 total
- Other minor peers for Emtricitabine/Tenofovir
- Valacyclovir
- Acyclovir
- Gentamicin
- Darunavir
0 major · 1 moderate · 13 minor · 14 total
- Other minor peers for Tenofovir Disoproxil
- Valacyclovir
- Acyclovir
- Gentamicin
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.