Metformin and Empagliflozin Interaction
Drug interaction information between Metformin and Empagliflozin.
Metformin and Empagliflozin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Metformin and Empagliflozin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these medicines together can increase the risk of a dangerous buildup of lactic acid in the blood. This risk is higher when other factors, such as alcohol, change how the body handles metformin.
FDA Label Information
Drugs that Reduce Metformin Clearance Clinical Impact Concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2 [OCT2] / multidrug and toxin extrusion [MATE] inhibitors such as ranolazine, vandetanib, dolutegravir, and cimetidine) could increase systemic exposure to metformin and may increase the risk for lactic acidosis [see Clinical Pharmacology (12.3) ] . Alcohol Clinical Impact Alcohol is known to potentiate the effect of metformin on lactate metabolism. ( 7 ) Drugs that...
Metformin Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir moderate
- Dolutegravir/Lamivudine moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
- Linagliptin moderate
Empagliflozin Also Interacts With
- Dolutegravir moderate
- Ranolazine moderate
- Metformin/Empagliflozin moderate
- Cimetidine moderate
- Topiramate minor
Frequently Asked Questions
What SPL severity band is on file for Metformin + Empagliflozin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metformin has 27 labeled pairs on file vs Empagliflozin's 10. In the moderate band specifically: Metformin has 10 (also Bictegravir, Dolutegravir/Lamivudine, Empagliflozin/Linagliptin, Ertugliflozin); Empagliflozin has 5 (also Dolutegravir, Ranolazine, Metformin/Empagliflozin, Cimetidine).
What mechanism field is on file for Metformin and Empagliflozin?
Using these medicines together can increase the risk of a dangerous buildup of lactic acid in the blood. This risk is higher when other factors, such as alcohol, change how the body handles metformin.
Metformin's labeled portfolio outnumbers Empagliflozin
SPL source-record counts only. This page's band is moderate · classes on file: Metformin (Biguanide); Empagliflozin (SGLT2 Inhibitor).
0 major · 10 moderate · 17 minor · 27 total
- Other moderate peers for Metformin
- Bictegravir
- Dolutegravir/Lamivudine
- Empagliflozin/Linagliptin
- Ertugliflozin
0 major · 5 moderate · 5 minor · 10 total
- Other moderate peers for Empagliflozin
- Dolutegravir
- Ranolazine
- Metformin/Empagliflozin
- Cimetidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.