Metformin and Empagliflozin/Linagliptin Interaction
Drug interaction information between Metformin and Empagliflozin/Linagliptin.
Metformin and Empagliflozin/Linagliptin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Metformin and Empagliflozin/Linagliptin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these medications together can cause metformin to build up in your blood because the kidneys cannot remove it as quickly. This increase can lead to a dangerous condition where too much acid builds up in your blood.
FDA Label Information
Drugs that Reduce Metformin Clearance Clinical Impact Concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2 [OCT2] / multidrug and toxin extrusion [MATE] inhibitors such as ranolazine, vandetanib, dolutegravir, and cimetidine) could increase systemic exposure to metformin and may increase the risk for lactic acidosis [see Clinical Pharmacology (12.3) ] . Alcohol Clinical Impact Alcohol is known to potentiate the effect of metformin on lactate metabolism. ( 7 ) Drugs that...
Metformin Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir moderate
- Dolutegravir/Lamivudine moderate
- Empagliflozin moderate
- Ertugliflozin moderate
- Linagliptin moderate
Empagliflozin/Linagliptin Also Interacts With
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Empagliflozin minor
- Topiramate minor
Frequently Asked Questions
What SPL severity band is on file for Metformin + Empagliflozin/Linagliptin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metformin has 27 labeled pairs on file vs Empagliflozin/Linagliptin's 11. In the moderate band specifically: Metformin has 10 (also Bictegravir, Dolutegravir/Lamivudine, Empagliflozin, Ertugliflozin); Empagliflozin/Linagliptin has 4 (also Dolutegravir, Ranolazine, Cimetidine).
What mechanism field is on file for Metformin and Empagliflozin/Linagliptin?
Taking these medications together can cause metformin to build up in your blood because the kidneys cannot remove it as quickly. This increase can lead to a dangerous condition where too much acid builds up in your blood.
Metformin's labeled portfolio outnumbers Empagliflozin/Linagliptin
SPL source-record counts only. This page's band is moderate · classes on file: Metformin (Biguanide); Empagliflozin/Linagliptin (SGLT2 / DPP-4 Combination).
0 major · 10 moderate · 17 minor · 27 total
- Other moderate peers for Metformin
- Bictegravir
- Dolutegravir/Lamivudine
- Empagliflozin
- Ertugliflozin
0 major · 4 moderate · 7 minor · 11 total
- Other moderate peers for Empagliflozin/Linagliptin
- Dolutegravir
- Ranolazine
- Cimetidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.