Metformin and Bictegravir Interaction
Drug interaction information between Metformin and Bictegravir.
Metformin and Bictegravir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Metformin and Bictegravir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This HIV medication can increase the amount of metformin that stays in your blood. This happens because the medicine interferes with how metformin is cleared from your system.
FDA Label Information
Metformin ↑ Metformin Refer to the prescribing information of metformin for assessing the benefit and risk of concomitant use of BIKTARVY and metformin.
Metformin Also Interacts With
- Dolutegravir/Lamivudine moderate
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
- Linagliptin moderate
Bictegravir Also Interacts With
- Rifampin major
- Dofetilide major
- Sertraline minor
- Estradiol minor
- Valacyclovir minor
Frequently Asked Questions
What SPL severity band is on file for Metformin + Bictegravir/Emtricitabine/Tenofovir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metformin has 27 labeled pairs on file vs Bictegravir's 19. In the moderate band specifically: Metformin has 10 (also Dolutegravir/Lamivudine, Empagliflozin, Empagliflozin/Linagliptin, Ertugliflozin); Bictegravir has 1.
What mechanism field is on file for Metformin and Bictegravir/Emtricitabine/Tenofovir?
This HIV medication can increase the amount of metformin that stays in your blood. This happens because the medicine interferes with how metformin is cleared from your system.
Bictegravir carries more major-labeled pairs than Metformin
SPL source-record counts only. This page's band is moderate · classes on file: Metformin (Biguanide); Bictegravir (Integrase Inhibitor / NRTI Combination).
Bictegravir has 2 major-labeled pairs vs Metformin's 0. This page itself is in the moderate band, not the major band.
0 major · 10 moderate · 17 minor · 27 total
- Other moderate peers for Metformin
- Dolutegravir/Lamivudine
- Empagliflozin
- Empagliflozin/Linagliptin
- Ertugliflozin
2 major · 1 moderate · 16 minor · 19 total
Bictegravir has no other moderate-band peer in this dataset besides Metformin.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.