Metformin and Dolutegravir Interaction
Drug interaction information between Metformin and Dolutegravir.
Metformin and Dolutegravir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Metformin and Dolutegravir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Dolutegravir slows down the process of removing metformin from your body. This can cause metformin to build up in your blood, increasing the risk of side effects.
FDA Label Information
Examples: Ranolazine, vandetanib, dolutegravir, and cimetidine. ( 7 ) Drugs that reduce metformin clearance (such as ranolazine, vandetanib, dolutegravir, and cimetidine) may increase the accumulation of metformin.
Metformin Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir moderate
- Dolutegravir/Lamivudine moderate
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
Dolutegravir Also Interacts With
- Dofetilide major
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
- Linagliptin moderate
Frequently Asked Questions
What SPL severity band is on file for Metformin + Dolutegravir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dolutegravir has 28 labeled pairs on file vs Metformin's 27. In the minor band specifically: Metformin has 17 (also Topiramate, Ranolazine, Cimetidine, Phenytoin); Dolutegravir has 21 (also Omeprazole, Prednisone, Estradiol, Carbamazepine).
What mechanism field is on file for Metformin and Dolutegravir?
Dolutegravir slows down the process of removing metformin from your body. This can cause metformin to build up in your blood, increasing the risk of side effects.
Dolutegravir carries more major-labeled pairs than Metformin
SPL source-record counts only. This page's band is minor · classes on file: Metformin (Biguanide); Dolutegravir (Integrase Strand Transfer Inhibitor).
Dolutegravir has 1 major-labeled pair vs Metformin's 0. This page itself is in the minor band, not the major band.
0 major · 10 moderate · 17 minor · 27 total
- Other minor peers for Metformin
- Topiramate
- Ranolazine
- Cimetidine
- Phenytoin
1 major · 6 moderate · 21 minor · 28 total
- Other minor peers for Dolutegravir
- Omeprazole
- Prednisone
- Estradiol
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.