What the FDA labels say about taking them together
Dolutegravir and metformin
Dolutegravir's FDA label of May 22, 2026 names metformin in its drug interactions section, and metformin's label names dolutegravir too. The metformin label: “Concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin could increase systemic exposure to metformin and may increase the risk for lactic …”
Check it at the source: the dolutegravir FDA label on DailyMed (effective May 22, 2026, ST. MARY'S MEDICAL PARK PHARMACY); the metformin FDA label on DailyMed (effective September 3, 2026, Granules India Ltd).
What does the dolutegravir label say about metformin?
Dolutegravir label, drug interactionsDolutegravir may increase plasma concentrations of drugs eliminated via OCT2 or MATE1 (dofetilide, dalfampridine, and metformin, Table 8 ) [see Contraindications ( 4 ), Drug Interactions ( 7.3 )].
Source: FDA drug label (Tivicay), NDA204790 (Viiv Hlthcare), as published by ST. MARY'S MEDICAL PARK PHARMACY, effective May 22, 2026 (SPL set 485bc9db-8665-9f5a-e063-6394a90a7921), via openFDA; the full label on DailyMed
What does the metformin label say about dolutegravir?
Metformin label, drug interactionsDrugs that Reduce Metformin Hydrochloride Extended-Release Tablets Clearance Clinical Impact: Concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (…) could increase systemic exposure to metformin and may increase the risk for lactic acidosis. Intervention: Consider the benefits and risks of concomitant use with metformin hydrochloride extended-release tablets. Examples: Ranolazine, vandetanib, dolutegravir, and cimetidine.
Riomet label (Sun Pharmaceutical Industries, Inc., December 6, 2018), drug interactions1. Examples:; 1. Ranolazine, vandetanib, dolutegravir, and cimetidine.
Source: FDA drug label (Riomet, NDA021591), Sun Pharmaceutical Industries, Inc., effective December 6, 2018 (SPL set 05d4df4b-dfe8-4828-b423-a3d4f2c4114a), via openFDA
Source: FDA drug label (METFORMIN HYDROCHLORIDE), Granules India Ltd, effective September 3, 2026 (SPL set 73197cb5-3e23-4ac0-b189-f9bc848bce66), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dolutegravir | Metformin | |
|---|---|---|
| Labeled for | HIV | Type 2 diabetes |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $77.64 per tablet 50 mg tablet | $0.0145 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once