What the FDA labels say about taking them together
Metformin and ranolazine
Metformin's FDA label of September 3, 2026 names ranolazine in its drug interactions section, and ranolazine's label names metformin too. The metformin label: “Concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin could increase systemic exposure to metformin and may increase the risk for lactic …”
Check it at the source: the metformin FDA label on DailyMed (effective September 3, 2026, Granules India Ltd); the ranolazine FDA label on DailyMed (effective January 23, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the metformin label say about ranolazine?
Metformin label, drug interactionsDrugs that Reduce Metformin Hydrochloride Extended-Release Tablets Clearance Clinical Impact: Concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (…) could increase systemic exposure to metformin and may increase the risk for lactic acidosis. Intervention: Consider the benefits and risks of concomitant use with metformin hydrochloride extended-release tablets. Examples: Ranolazine, vandetanib, dolutegravir, and cimetidine.
Riomet label (Sun Pharmaceutical Industries, Inc., December 6, 2018), drug interactions1. Examples:; 1. Ranolazine, vandetanib, dolutegravir, and cimetidine.
Source: FDA drug label (Riomet, NDA021591), Sun Pharmaceutical Industries, Inc., effective December 6, 2018 (SPL set 05d4df4b-dfe8-4828-b423-a3d4f2c4114a), via openFDA
Source: FDA drug label (METFORMIN HYDROCHLORIDE), Granules India Ltd, effective September 3, 2026 (SPL set 73197cb5-3e23-4ac0-b189-f9bc848bce66), via openFDA; the full label on DailyMed
What does the ranolazine label say about metformin?
Ranolazine label, drug interactionsDrugs Transported by OCT2 In subjects with type 2 diabetes mellitus, concomitant use of ranolazine extended-release tablets 1000 mg twice daily and metformin results in increased plasma levels of metformin.
Source: FDA drug label (Aspruzyo Sprinkle, NDA216018), SUN PHARMACEUTICAL INDUSTRIES, INC., effective January 29, 2025 (SPL set dd9f81e4-50da-4551-aed5-559d304df42e), via openFDA
Source: FDA drug label (Ranolazine), Glenmark Pharmaceuticals Inc., USA, effective January 23, 2026 (SPL set 0cf58732-c242-49b0-8e3f-248778b4458d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Metformin | Ranolazine | |
|---|---|---|
| Labeled for | Type 2 diabetes | Angina |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0145 per tablet 500 mg tablet | $0.165 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once