Desipramine and Duloxetine Interaction
Drug interaction information between Desipramine and Duloxetine.
Desipramine and Duloxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Desipramine and Duloxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Duloxetine slows down the body's ability to process desipramine. This can cause desipramine levels to increase by about three times the normal amount.
FDA Label Information
When duloxetine was administered (at a dose of 60 mg twice daily) in conjunction with a single 50 mg dose of desipramine, a CYP2D6 substrate, the AUC of desipramine increased 3-fold [see Warnings and Precautions (5.12) ].
Desipramine Also Interacts With
- Atomoxetine minor
- Bupropion minor
- Darunavir minor
- Desvenlafaxine minor
- Dopamine minor
Duloxetine Also Interacts With
- Aspirin moderate
- Fluoxetine minor
- Famotidine minor
- Buspirone minor
- Paroxetine minor
Frequently Asked Questions
What SPL severity band is on file for Desipramine + Duloxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's minor band?
Desipramine and Duloxetine tie at 18 labeled pairs each. minor-band counts: Desipramine 18 alongside Atomoxetine, Bupropion, Darunavir, Desvenlafaxine; Duloxetine 17 alongside Fluoxetine, Famotidine, Buspirone, Paroxetine.
What mechanism field is on file for Desipramine and Duloxetine?
Duloxetine slows down the body's ability to process desipramine. This can cause desipramine levels to increase by about three times the normal amount.
Desipramine and Duloxetine · minor-band peers
SPL source-record counts only. This page's band is minor · classes on file: Desipramine (Tricyclic Antidepressant (TCA)); Duloxetine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
0 major · 0 moderate · 18 minor · 18 total
- Other minor peers for Desipramine
- Atomoxetine
- Bupropion
- Darunavir
- Desvenlafaxine
0 major · 1 moderate · 17 minor · 18 total
- Other minor peers for Duloxetine
- Fluoxetine
- Famotidine
- Buspirone
- Paroxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.