Lansoprazole and Tacrolimus Topical Interaction
Drug interaction information between Lansoprazole and Tacrolimus Topical.
Lansoprazole and Tacrolimus Topical have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Lansoprazole and Tacrolimus Topical. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Lansoprazole makes it harder for your body to get rid of tacrolimus. This can cause the medicine to build up to unsafe levels in your system.
FDA Label Information
Mild or Moderate CYP3A Inhibitors: Clotrimazole, antibiotics (e.g., verapamil, diltiazem, nifedipine, nicardipine), amiodarone, danazol, ethinyl estradiol, cimetidine, lansoprazole and omeprazole May increase tacrolimus whole blood trough concentrations and increase the risk of serious adverse reactions (e.g., neurotoxicity, QT prolongation) [see Warnings and Precautions ( 5.7 , 5.10 , 5.11 )] .
Lansoprazole Also Interacts With
- Amoxicillin major
- Clarithromycin major
- Rifampin moderate
- Warfarin minor
- Methotrexate minor
Tacrolimus Topical Also Interacts With
- Omeprazole moderate
- Estradiol moderate
- Diltiazem moderate
- Nifedipine moderate
- Ketoconazole moderate
Frequently Asked Questions
What SPL severity band is on file for Lansoprazole + Tacrolimus Topical?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tacrolimus Topical has 25 labeled pairs on file vs Lansoprazole's 14. In the moderate band specifically: Lansoprazole has 2 (also Rifampin); Tacrolimus Topical has 19 (also Omeprazole, Estradiol, Diltiazem, Nifedipine).
What mechanism field is on file for Lansoprazole and Tacrolimus Topical?
Lansoprazole makes it harder for your body to get rid of tacrolimus. This can cause the medicine to build up to unsafe levels in your system.
Lansoprazole carries more major-labeled pairs than Tacrolimus Topical
SPL source-record counts only. This page's band is moderate · classes on file: Lansoprazole (Proton Pump Inhibitor (PPI)); Tacrolimus Topical (Calcineurin Inhibitor (Topical)).
Lansoprazole has 2 major-labeled pairs vs Tacrolimus Topical's 0. This page itself is in the moderate band, not the major band.
2 major · 2 moderate · 10 minor · 14 total
- Other moderate peers for Lansoprazole
- Rifampin
0 major · 19 moderate · 6 minor · 25 total
- Other moderate peers for Tacrolimus Topical
- Omeprazole
- Estradiol
- Diltiazem
- Nifedipine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.