Lansoprazole and Rifampin Interaction
Drug interaction information between Lansoprazole and Rifampin.
Lansoprazole and Rifampin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Lansoprazole and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin causes the body to break down lansoprazole too quickly, which makes the medicine less effective.
FDA Label Information
Clinically Relevant Interactions Affecting Lansoprazole Delayed Release Capsules When CoAdministered with Other Drugs CYP2C19 OR CYP3A4 Inducers Clinical Impact: Decreased exposure of lansoprazole when used concomitantly with strong inducers [ see Clinical Pharmacology ( 12.3 )] Intervention : St John’s Wort, rifampin : Avoid concomitant use with Lansoprazole.
Lansoprazole Also Interacts With
- Amoxicillin major
- Clarithromycin major
- Tacrolimus Topical moderate
- Warfarin minor
- Methotrexate minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Lansoprazole + Rifampin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Lansoprazole's 14. In the moderate band specifically: Lansoprazole has 2 (also Tacrolimus Topical); Rifampin has 26 (also Doxycycline, Probenecid, Theophylline, Apixaban).
What mechanism field is on file for Lansoprazole and Rifampin?
Rifampin causes the body to break down lansoprazole too quickly, which makes the medicine less effective.
Rifampin carries more major-labeled pairs than Lansoprazole
SPL source-record counts only. This page's band is moderate · classes on file: Lansoprazole (Proton Pump Inhibitor (PPI)); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Lansoprazole's 2. This page itself is in the moderate band, not the major band.
2 major · 2 moderate · 10 minor · 14 total
- Other moderate peers for Lansoprazole
- Tacrolimus Topical
8 major · 26 moderate · 103 minor · 137 total
- Other moderate peers for Rifampin
- Doxycycline
- Probenecid
- Theophylline
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.