What the FDA labels say about taking them together
Lansoprazole and rifampin
Lansoprazole's FDA label of June 24, 2025 names rifampin in its drug interactions (prescription label) section; the rifampin label PlainMeds reads does not name lansoprazole. The lansoprazole label: “Decreased exposure of lansoprazole when used concomitantly with strong inducers.”
Check it at the source: the lansoprazole FDA label on DailyMed (effective June 24, 2025, L. Perrigo Company); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the lansoprazole label say about rifampin?
Lansoprazole label, drug interactions (prescription label)CYP2C19 OR CYP3A4 Inducers Clinical Impact: Decreased exposure of lansoprazole when used concomitantly with strong inducers. Intervention: St John's Wort, rifampin: Avoid concomitant use with PREVACID or PREVACID SoluTab. Ritonavir-containing products: See prescribing information.
Source: FDA drug label (Prevacid 24 HR), L. Perrigo Company, effective June 24, 2025 (SPL set 205c9c1e-b422-4e86-a4b0-714b608adc19), via openFDA; the full label on DailyMed
What does the rifampin label say about lansoprazole?
Rifampin's label (effective February 11, 2026) does not name lansoprazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lansoprazole | Rifampin | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.106 per capsule 30 mg capsule | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once