Lansoprazole and Warfarin Interaction
Drug interaction information between Lansoprazole and Warfarin.
Lansoprazole and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lansoprazole and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Lansoprazole can change how your body handles warfarin, which can make your blood thinner than it should be.
FDA Label Information
Warfarin Clinical Impact: Increased INR and prothrombin time in patients receiving PPIs and warfarin concomitantly. Dose adjustment of warfarin may be needed to maintain target INR range. See prescribing information for warfarin.
Lansoprazole Also Interacts With
- Amoxicillin major
- Clarithromycin major
- Rifampin moderate
- Tacrolimus Topical moderate
- Methotrexate minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Lansoprazole + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Lansoprazole's 14. In the minor band specifically: Lansoprazole has 10 (also Methotrexate, Ketoconazole, Itraconazole, Voriconazole); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Lansoprazole and Warfarin?
Lansoprazole can change how your body handles warfarin, which can make your blood thinner than it should be.
Warfarin's labeled portfolio outnumbers Lansoprazole
SPL source-record counts only. This page's band is minor · classes on file: Lansoprazole (Proton Pump Inhibitor (PPI)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
2 major · 2 moderate · 10 minor · 14 total
- Other minor peers for Lansoprazole
- Methotrexate
- Ketoconazole
- Itraconazole
- Voriconazole
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.